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RECRUITINGINTERVENTIONAL

Neuromodulation in Patients With Neuropathic Pain and Depression.

Neuromodulation in Patients With Neuropathic Pain and Depression: a Cross-over Study Between Two Targets in Transcranial Magnetic Stimulation, the Primary Motor Cortex and the Dorsolateral Prefrontal Cortex.

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

High-frequency repetitive transcranial magnetic stimulation of the primary motor cortex has shown its effect on refractory neuropathic pain, and rTMS of the dorsolateral prefrontal cortex is commonly used for treatment-resistant depression. The treatment for patients suffering from neuropathic pain and depression, concomitantly, still needs to be studied, as there are some specificities in both symptoms and brain functional MRI.

Who May Be Eligible (Plain English)

Who May Qualify: - Central or peripheral neuropathic pain - Chronic pain (present for more than 6 months) with intensity greater than or equal to 4/10 on the numerical scale - Pain present on a daily or near-daily basis (at least 4 days a week) - Patient not completely relieved by recommended drug treatments for first- and second-line neuropathic pain - Stable analgesic treatment (no new treatment or dosage adjustment) for at least one month, and will not need to be modified for the duration of the study. - Patient with a depressive episode characterized according to DSM V criteria - Indication for motor cortex rTMS by a neurologist - Patient can be followed for the entire duration of the study - Patient having received willing to sign a consent form to participate in the study, and having co-signed a consent form with the investigator - Member or beneficiary of a social security scheme Who Should NOT Join This Trial: - Industrial accident or litigation - Contraindication to rTMS or MRI (seismotherapy treatment since the previous month; epilepsy and/or history of epilepsy; history of head trauma; neurosurgical lesion; intracranial hypertension; intracerebral metal clip; piercing; pacemaker; insulin pump; metal prosthesis; pregnant or breast-feeding woman; claustrophobia) - Drug or psychoactive substance abuse - Neuropathic pain in the context of a progressive pathology (HIV, cancer, systemic disease disease) - Presence of other pain more severe than that justifying inclusion - Patient unable to understand willing to sign a consent form - Patient unwilling or unable to stop treatments prohibited during the study - Patient participating in another research protocol involving a drug within the 30 days prior to inclusion - Patient deprived of liberty or under legal protection (guardianship, curatorship, safeguard of justice safeguard, family safeguard) - Minor patient Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Central or peripheral neuropathic pain * Chronic pain (present for more than 6 months) with intensity greater than or equal to 4/10 on the numerical scale * Pain present on a daily or near-daily basis (at least 4 days a week) * Patient not completely relieved by recommended drug treatments for first- and second-line neuropathic pain * Stable analgesic treatment (no new treatment or dosage adjustment) for at least one month, and will not need to be modified for the duration of the study. * Patient with a depressive episode characterized according to DSM V criteria * Indication for motor cortex rTMS by a neurologist * Patient can be followed for the entire duration of the study * Patient having received informed consent to participate in the study, and having co-signed a consent form with the investigator * Member or beneficiary of a social security scheme Exclusion Criteria: * Industrial accident or litigation * Contraindication to rTMS or MRI (seismotherapy treatment since the previous month; epilepsy and/or history of epilepsy; history of head trauma; neurosurgical lesion; intracranial hypertension; intracerebral metal clip; piercing; pacemaker; insulin pump; metal prosthesis; pregnant or breast-feeding woman; claustrophobia) * Drug or psychoactive substance abuse * Neuropathic pain in the context of a progressive pathology (HIV, cancer, systemic disease disease) * Presence of other pain more severe than that justifying inclusion * Patient unable to understand informed consent * Patient unwilling or unable to stop treatments prohibited during the study * Patient participating in another research protocol involving a drug within the 30 days prior to inclusion * Patient deprived of liberty or under legal protection (guardianship, curatorship, safeguard of justice safeguard, family safeguard) * Minor patient

Treatments Being Tested

DEVICE

Repetitive transcranial magnetic stimulation (rTMS) - M1/DLPFC

Repetitive transcranial magnetic stimulation (rTMS) is a treatment technique involving the induction of an electrical current on the surface of the cortex by applying a magnetic field to the scalp. This field is generated using a stimulation loop controlled by a robotic arm linked to a neuronavigation system. rTMS of M1 then rTMS of DLPFC.

DEVICE

Repetitive transcranial magnetic stimulation (rTMS) - DLPFC/M1

Repetitive transcranial magnetic stimulation (rTMS) is a treatment technique involving the induction of an electrical current on the surface of the cortex by applying a magnetic field to the scalp. This field is generated using a stimulation loop controlled by a robotic arm linked to a neuronavigation system. rTMS of DLPFC then rTMS of M1.

Locations (1)

CHU de Saint-Etienne
Saint-Etienne, France