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RECRUITINGINTERVENTIONAL

Rehabilitation of People With Post-tuberculosis Lung Disease

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Tuberculosis (TB) can leave numerous sequelae, where survivors experience a transition from an acute illness to living with a multifaceted chronic illness. Post-TB lung disease (PD-PTB) encompasses lung diseases and pathologies that occur after one or more episodes of TB, which can affect the patient's lung health and cause disabling symptoms that strongly affect their long-term health. In 2020, it was estimated that there were 155 million TB survivors still alive worldwide, with a large proportion of them carrying functional sequelae with profound socioeconomic repercussions. Thus, the aim of this study is to evaluate the effect of pulmonary rehabilitation (PR) on functionality and health-related quality of life (HRQoL) of people with PD-PTB and to build a PD-PTB severity scoring system based on the data. of pre-RP individuals using artificial intelligence technique.

Who May Be Eligible (Plain English)

Who May Qualify: - Patients with post-tuberculosis lung disease, clinically stable and able to perform \>80% of training sessions. Who Should NOT Join This Trial: - Presence of comorbidities not related to PD-PTB. - Patients with inability to perform TGlittre. - Patients who have cognitive changes that impair their inclusion in the study. - Treatment abandonment during the application of the PR protocol. - Uncontrolled hypertension or use of psychotropic medications. - Any significant limitations due to osteoarthropathy. - Having had any orthopedic surgery in the previous year. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Patients with post-tuberculosis lung disease, clinically stable and able to perform \>80% of training sessions. Exclusion Criteria: * Presence of comorbidities not related to PD-PTB. * Patients with inability to perform TGlittre. * Patients who have cognitive changes that impair their inclusion in the study. * Treatment abandonment during the application of the PR protocol. * Uncontrolled hypertension or use of psychotropic medications. * Any significant limitations due to osteoarthropathy. * Having had any orthopedic surgery in the previous year.

Treatments Being Tested

OTHER

Standard care plus pulmonary rehabilitation

A 12-week rehabilitation program, 3X/week. Each outpatient session will last 2 hours including: guidance on the care of inhalation techniques and/or oxygen therapy, when prescribed; aerobic training on a cycle ergometer supervised by a physiotherapist (30 min each: 5 min warm-up, 20 min training and 5 min cool-down) at constant load calculated with Hill's equation (HILL et al., 2008). Optional components of RP will include: inspiratory muscle conditioning using a threshold-loading device, inspiratory muscle training with powerbreathe, breathing exercises, airway clearance, psychological support, relaxation and nutritional counseling. Patients will participate in two group educational sessions, managed by a respiratory physiotherapist, on lifestyle, physical activity and maintenance programs (VISCA et al., 2019; FUGAZZARO et al., 2017; TENCONI et al., 2021).

OTHER

Standard Care

Participants will receive standard care (SC): a therapeutic education session upon admission, as well as pulmonary rehabilitation (PR) taught by a physical therapist. This therapeutic educational session will involve counseling and self-care management, emphasizing breathing exercises and sputum clearance and self-care techniques. It will consist of smoking cessation education (if this is the case, as tobacco is associated with TB), respiratory retraining (pursed lip breathing, diaphragmatic breathing and segmental breathing) and secretion removal training (coughing exercise, huffing , assisted cough and postural drainage).

Locations (2)

Agnaldo José Lopes
Rio de Janeiro, Brazil
Centro Universitario Augusto Motta
Rio de Janeiro, Brazil