Endoluminal Vacuum Therapy to Prevent Anastomotic Leakage After Esophagectomy Due to Esophageal Cancer

Who May Qualify: - Age ≥ 18 years - Scheduled for total minimally invasive (laparoscopic or robotic and thoracoscopic) transthoracic Ivor Lewis esophagectomy (ttMILE) due to esophageal cancer and subsequent eso-SPONGE application to prevent anastomotic leakage - Patients able to read and understand the Patient Information Sheet and sign, if accepted, the willing to sign a consent form Form - Patients able, at the discretion of the investigator, to comply with the requirements of the study and without impediments to follow the instructions and assessments throughout the study. Who Should NOT Join This Trial: - Patients undergoing transhiatal esophagectomy without reconstruction, open Ivor Lewis esophagectomy or other esophageal resections different to ttMILE. - Multi-organ resection during the esophagectomy. - Emergent-urgent esophagectomy. - Coloplasty or small bowel plasty. - Necrotic tissue/gangrene. - Blood clotting disorder. - Bleeding esophageal varices. - Sponge placement required directly on major vessels. - Patients with known sensitivities or allergies to its components - Participation in any other clinical trial and use of any drug or experimental device, currently or in the 4 weeks prior to inclusion in the study. - Women who are pregnant, suspected of being pregnant or breastfeeding. Always talk to your doctor about whether this trial is right for you.