CW2IP2: Imaging and Diagnostic Assessments

Who May Qualify: - Participants: Patients in all cohorts will range from 40 to 85 yrs and will be both male and female. - Participants must be informed of the investigational nature of this study and be willing to provide written willing to sign a consent form and participate in this study in accordance with institutional and federal guidelines prior to study-specific procedures. Participants who are deemed unable to provide willing to sign a consent form must have a designated Legally Authorized Representative(LAR) present for consent and a Study Partner to accompany them to study visits. The LAR and the Study Partner may be the same person. - Clinical diagnoses for each cohort will be determined by consensus committee for diagnostic agreement (PD, MSA, PSP, FTD or Healthy control) Who Should NOT Join This Trial: - Females who are pregnant or breast feeding at the time of screening will be excluded - Forms of parkinsonism other than PD, PSP and MSA as defined above - Major psychiatric disorder (e.g. schizophrenia or bipolar disorder) - History of significant or ongoing alcohol abuse or substance abuse or dependence based on medical record review or self-reported - Contraindications or Inability to tolerate imaging, arterial line or IV placement or blood draw procedures in the opinion of an investigator or treating physician - Implanted medical device or other contraindication to MRI - Any current medical condition, illness, or disorder as assessed by medical record review and/or self-reported that is considered by a physician or investigator to be a condition that could compromise participant safety or successful participation in the study - Refusal to consent to brain donation (except for HC cohort). All non-HC participants must agree to postmortem brain donation.. Always talk to your doctor about whether this trial is right for you.