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RECRUITINGOBSERVATIONAL

Active Screening of Latent Tuberculosis Infection in School Contacts of Active Tuberculosis Patients

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The goal of this observational study is to investigate the proportion of Mycobacterium tuberculosis (MTB) infection in school contacts of active tuberculosis (ATB) patients. The main questions it aims to answer are: * the proportion of MTB infection among school contacts of ATB patients * risk factors related to tuberculosis (TB) infection * health economic evaluation of screening strategy

Who May Be Eligible (Plain English)

Who May Qualify: - 13 years old or above; - Students in junior middle school, high school and university; - Close contact of school active tuberculosis case (e.g. in the same classroom, in the same dormitory); - Himself/herself (together with his/her guardian for age under 18 years old) willing to participate in trial and sign willing to sign a consent form. Who Should NOT Join This Trial: - Current clinical or sputum culture confirmed active tuberculosis - Have completed a full course of treatment for ATB or LTBI Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * 13 years old or above; * Students in junior middle school, high school and university; * Close contact of school active tuberculosis case (e.g. in the same classroom, in the same dormitory); * Himself/herself (together with his/her guardian for age under 18 years old) willing to participate in trial and sign informed consent. Exclusion Criteria: * Current clinical or sputum culture confirmed active tuberculosis * Have completed a full course of treatment for ATB or LTBI

Treatments Being Tested

DIAGNOSTIC_TEST

QuantiFERON-TB Gold (QFT) test

Participants will be tested by QuantiFERON-TB Gold (QFT) test to see if they have ever infected by MTB. Those with positive results will proceed to sputum Xpert MTB/RIF, physical examination and chest CT scan, as well as sputum culture if necessary to distinguish latent TB infection (LTBI) from ATB. X-ray scan is conditional on age above 15 years with a positive QuantiFERON-TB Gold (QFT) test result.

Locations (20)

Xinpu New Area Center of Disease Control
Zunyi, Guiyang, China
Dafang Center for Disease Control and Prevention
Bijie, Guizhou, China
Qixingguan Center for Disease Control and Prevention
Bijie, Guizhou, China
Nayong Center for Disease Control and Prevention
Bijie, Guizhou, China
Hezhang Center for Disease Control
Bijie, Guizhou, China
Jinsha Center for Disease Control
Bijie, Guizhou, China
Qianxi Center of Disease Control
Bijie, Guizhou, China
Weining Center of Disease Control
Bijie, Guizhou, China
Zhijin Center of Disease Control
Bijie, Guizhou, China
Liping Center for Disease Control and Prevention
Linping, Guizhou, China
Liuzhi Special District Center of Disease Control
Liupanshui, Guizhou, China
Panzhou Center of Disease Control
Liupanshui, Guizhou, China
Shuicheng District Center of Disease Control
Liupanshui, Guizhou, China
Cengong Center of Disease Control
Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Congjiang Ceter of Disease Control
Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Danzhai Center of Disease Control
Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Huangping Center of Disease Control
Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Jianhe Center of Disease Control
Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Jinping Center of Disease Control
Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Kaili Center of Disease Control
Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China