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RECRUITINGPhase 2INTERVENTIONAL

Psilocybin-Assisted Psychotherapy for Alcohol Use Disorder

Mechanisms Supporting Psilocybin-assisted Psychotherapy for Alcohol Use Disorder: A Randomized, Controlled Clinical Trial

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The aim of this study is to determine if a single dose of psilocybin administered with motivational enhancement therapy (MET) can reduce heavy drinking in patients with an alcohol use disorder (AUD).

Who May Be Eligible (Plain English)

Who May Qualify: - Meets DSM-5 AUD criteria of at least moderate severity - Meets heavy drinking requirements (heavy drinking days, number of drinks) in past 30 days - Desire to decrease alcohol consumption - Limited lifetime hallucinogen use Who Should NOT Join This Trial: - Severe or moderate substance use disorder other than alcohol or nicotine in past 6 months - Diagnosis of schizophrenia, bipolar disorders or first-degree relative with diagnosis - Active suicidal ideation or serious attempt within past 3 years - Currently pregnant, nursing, or trying to become pregnant - Any notable abnormality on ECG, physical exam, or routine medical blood laboratory test Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Meets DSM-5 AUD criteria of at least moderate severity * Meets heavy drinking requirements (heavy drinking days, number of drinks) in past 30 days * Desire to decrease alcohol consumption * Limited lifetime hallucinogen use Exclusion Criteria: * Severe or moderate substance use disorder other than alcohol or nicotine in past 6 months * Diagnosis of schizophrenia, bipolar disorders or first-degree relative with diagnosis * Active suicidal ideation or serious attempt within past 3 years * Currently pregnant, nursing, or trying to become pregnant * Any notable abnormality on ECG, physical exam, or routine medical blood laboratory test

Treatments Being Tested

DRUG

Psilocybin

Single dosing session followed by 5 MET weekly sessions starting 24hrs after dosing

Locations (1)

University of Calgary
Calgary, Alberta, Canada