RECRUITINGOBSERVATIONAL
The Daytime Circadian Rhythm in Exhaled Volatile Organic Compounds in People Living Without and Diabetes
The Daytime Circadian Rhythm in Exhaled Volatile Organic Compounds in People Living Without and With Type 1 and 2 Diabetes: an Exploratory Study
About This Trial
Exhaled volatile organic compounds will be measured during daytime with the goal to identifying circadian variability. The study incudes three subgroups: people without diabetes, people with type 1 diabetes, and people with type 2 diabetes. A total of 60 people will be recruited for the study.
Who May Be Eligible (Plain English)
Inclusion criteria
Subgroup 1:
- Age 18 or older
- HbA1c below 6.5%
- Written willing to sign a consent form
Subgroup 2:
- Age 18 or older
- T1D (Type 1 diabetes) with MDI (multiple daily injection) or CSII (Continuous subcutaneous insulin infusion therapy) therapy \>1 year
- Written willing to sign a consent form
Subgroup 3
- Age 18 or older
- T2D (Type 2 diabetes) with oral antidiabetic medication or insulin therapy
- Written willing to sign a consent form
Exclusion criteria
- Pregnancy or breastfeeding
- Smoking (last cigarette less than 6 months ago)
- Any chronical lung and intestinal disease diagnosis (such as intestinal bowel disease (IBD); asthma; COPD (chronic obstructive pulmonary disease); lung cancer, …)
- Coeliac disease
- Lactose and fructose intolerance
- Any acute disease diagnosis (such as viral or bacterial infection)
- Drinking habit of more than four units of alcohol per day
- Current inhaled medicines treatments
- Antibiotic treatment in the previous 4 months
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion criteria
Subgroup 1:
* Age 18 or older
* HbA1c below 6.5%
* Written informed consent
Subgroup 2:
* Age 18 or older
* T1D (Type 1 diabetes) with MDI (multiple daily injection) or CSII (Continuous subcutaneous insulin infusion therapy) therapy \>1 year
* Written informed consent
Subgroup 3
* Age 18 or older
* T2D (Type 2 diabetes) with oral antidiabetic medication or insulin therapy
* Written informed consent
Exclusion criteria
* Pregnancy or breastfeeding
* Smoking (last cigarette less than 6 months ago)
* Any chronical lung and intestinal disease diagnosis (such as intestinal bowel disease (IBD); asthma; COPD (chronic obstructive pulmonary disease); lung cancer, …)
* Coeliac disease
* Lactose and fructose intolerance
* Any acute disease diagnosis (such as viral or bacterial infection)
* Drinking habit of more than four units of alcohol per day
* Current inhaled medicines treatments
* Antibiotic treatment in the previous 4 months
Treatments Being Tested
OTHER
Standardized meal
The participants will receive a standardized meal for breakfast
Locations (1)
University of Bern
Bern, Switzerland