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RECRUITINGOBSERVATIONAL

Circadian Rhythm and Other Factors in Memory Clinic Patients

Circadian Rhythm and Other Individual Factors Among Memory Clinic Patients

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The CIRCAME study is a bicentric study of patients from 2 memory clinics in Paris. The main objective is to identify circadian rhythm components and other individual risk factors (sociodemographic, behavioral, and health related factors) associated with the diagnosis of subtypes (AD, Lewy bodies, vascular, frontotemporal dementia) and stages (cognitively healthy, mild cognitive impairment, clinical dementia) of dementia, independent of known risk factors (sociodemographic and genetic) and assess the relevance of use of these factors in primary care for screen of dementia including subtypes and stages. A secondary objective is to determine factors associated with progression of the disease, in terms of cognitive decline and limitations in activities of daily living, as well as progression to dementia among cognitively healthy controls and patients with mild cognitive impairment, up to 15 years after the inclusion period.

Who May Be Eligible (Plain English)

Who May Qualify: - Patient of legal age (18 or over) - Signed willing to sign a consent form form - Patient affiliated to the french social security system Who Should NOT Join This Trial: - Skin allergy to plastic - Diagnosis of psychiatric disorder that can explain all cognitive symptoms - Inability to come accompanied for patients with a Mini-Mental State Examination (MMSE) cognitive score ≤18 or a clinician assessment indicating the need to be accompanied (e.g. wheelchair use, agitation) - Participation at the time of inclusion and during the 9-day period of wearing the accelerometer in interventional research with potential impact on circadian rhythm Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Patient of legal age (18 or over) * Signed informed consent form * Patient affiliated to the french social security system Exclusion Criteria: * Skin allergy to plastic * Diagnosis of psychiatric disorder that can explain all cognitive symptoms * Inability to come accompanied for patients with a Mini-Mental State Examination (MMSE) cognitive score ≤18 or a clinician assessment indicating the need to be accompanied (e.g. wheelchair use, agitation) * Participation at the time of inclusion and during the 9-day period of wearing the accelerometer in interventional research with potential impact on circadian rhythm

Treatments Being Tested

OTHER

Questionnaire

The questionnaire includes information on socio-demographics (age, sex, education, occupation, marital status), behavioural (smoking, alcohol consumption, social functioning), and health-related factors (morbidities, treatment, sleep disturbance, eye diseases, frailty, falls).

OTHER

Clinical examination

This includes earing test, cognitive tests (mini-mental status examination, MemScreen), body mass index, waist circumference, blood pressure and blood tests (biomarkers of Alzheimer's disease, neurodegeneration, and other dementias).

OTHER

Accelerometer port

Participants will be wearing an accelerometer for 9 days.

OTHER

Eye examination

Eye fundus photo, OCT and OCT-A exams

OTHER

Ear Examination

Otoscopic examination, Wideband tympanometry, Pure-tone and speech audiometry (in quiet and in noise), Auditory evoked potentials, Electroencephalogram with auditory stimulation

Locations (2)

Centre de neurologie Cognitive / CMRR
Paris, France, France
Hôpital de Jour Gériatrique et consultation mémoire
Paris, France, France