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RECRUITINGINTERVENTIONAL

NC Testing in LC & POTS

Neurocognitive Testing in Long COVID and Postural Tachycardia Syndrome Patients with Normal Saline: a Pilot Study

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Patients with Postural Orthostatic Tachycardia Syndrome (POTS) and Post-Acute Sequelae of COVID (PASC, or "Long COVID") experience cognitive dysfunction. The investigators will test the hypothesis that 999 mL of IV saline will improve cognitive function in patients with POTS and Long COVID compared to placebo (50 mL of saline).

Who May Be Eligible (Plain English)

Who May Qualify: - Patients with diagnosis of Long COVID - SARS-COV2 test positive - Symptoms \> 12 weeks post COVID - Subjective complaint of 'brain fog" or cognitive dysfunction - Patients with diagnosis of Postural Orthostatic Syndrome (POTS) from the Calgary Autonomic Investigation and Management Clinic - Subjective complaint of 'brain fog" or cognitive impairment - Healthy participants - Without POTS or "brain fog" - Age 18 to 60 years - Female and Male - Able to give an willing to sign a consent form Who Should NOT Join This Trial: - Patients with overt causes for POTS (e.g., dehydration, prolonged bed rest) - An inability to safely withdraw from medicine(s) that could make test interpretation difficult and impossible. - Other factors which are in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies or an unpredictable schedule. - Unable to give an willing to sign a consent form. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Patients with diagnosis of Long COVID * SARS-COV2 test positive * Symptoms \> 12 weeks post COVID * Subjective complaint of 'brain fog" or cognitive dysfunction * Patients with diagnosis of Postural Orthostatic Syndrome (POTS) from the Calgary Autonomic Investigation and Management Clinic * Subjective complaint of 'brain fog" or cognitive impairment * Healthy participants * Without POTS or "brain fog" * Age 18 to 60 years * Female and Male * Able to give an informed consent Exclusion Criteria: * Patients with overt causes for POTS (e.g., dehydration, prolonged bed rest) * An inability to safely withdraw from medicine(s) that could make test interpretation difficult and impossible. * Other factors which are in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies or an unpredictable schedule. * Unable to give an informed consent.

Treatments Being Tested

OTHER

IV normal saline (999 mL infusion)

999 mL of IV normal saline will be infused intravenously

OTHER

IV normal saline (50 mL infusion)

50 mL of IV normal saline will be infused intravenously as a placebo control.

Locations (1)

University of Calgary
Calgary, Alberta, Canada