RECRUITINGINTERVENTIONAL

Direct Discrimination of Quantum States by the Human Eye

Direct Discrimination of Quantum States by the Human Eye With Macular Degeneration

About This Trial

Age-related macular degeneration (AMD), is a debilitating eye disease that causes a loss of central vision. The prevalence of AMD increases exponentially with age and causes a significant impact through both medical expenses and the social and economic costs associated with vision loss. AMD is the global leading cause of blindness among people over the age of 60. Detection of this eye disease at early stages coupled with prompt treatment can prevent vision loss; however, modern diagnosis methods are ineffective at diagnosis of AMD before vision loss occurs. While a range of available treatment options has been effective at slowing vision loss due to AMD, no treatment exists which can recover lost vision. The investigators propose to apply tools developed in quantum information science to diagnose AMD before vision has been affected, drastically improving health outcomes for patients with AMD.

Who May Be Eligible (Plain English)

Who May Qualify: - Participants who are clinically diagnosed with a vision disease affecting their macula - Older adults who are matched for age. - Participants who are clinically diagnosed with glaucoma - Participants who have normal vision. - One aged-matched control with normal vision will be recruited for each of the diagnosed groups (born in the same year). Who Should NOT Join This Trial: - Participants with any additional eye diagnosis or condition Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria: * Participants who are clinically diagnosed with a vision disease affecting their macula * Older adults who are matched for age. * Participants who are clinically diagnosed with glaucoma * Participants who have normal vision. * One aged-matched control with normal vision will be recruited for each of the diagnosed groups (born in the same year). Exclusion Criteria: * Participants with any additional eye diagnosis or condition

Treatments Being Tested

DEVICE

Structured Light Imaging Microscopy

Conducting the psychophysical task on the perception of OAM-coupled polarized light created using the experimental setup - Structured Light Imaging Microscopy (SLIM). Four types of vortex orbital angular momentum, differing by the number of fringes l=5;10; 15;20, will be presented for 0.5s per trial during which an azimuthally varying entoptic profile rotated clockwise or counterclockwise. A circular mask with a varying radius will be placed at fixation, thus the task will be performed at varying eccentricities. Circular obstruction of the area will be achieved due to the high refresh-rate structured light modulator. The threshold mask size will be changed by a 2up/1down staircase method (71% accuracy for the estimation of mask size).

Locations (1)

Centre for Eye and Vision Research Limited

Hong Kong, Guangdong, Hong Kong