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RECRUITINGINTERVENTIONAL

ITreatOCD: Predicting the Efficacy of Internet-based Cognitive Behavioral Therapy in Obsessive-compulsive Disorder

ITreatOCD: Predicting the Efficacy of Internet-based Cognitive Behavioral Therapy from Changes in the Neurobiological Correlates of Emotion Regulation in Obsessive-compulsive Disorder

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

In the current study, the investigators will characterize obsessive-compulsive disorder (OCD) patients and healthy controls with a comprehensive clinical and neuroimaging assessment, focusing on the basic psychological processes related and on the neurobiological underpinnings of emotion regulation (ER). After a baseline assessment, the investigators will implement an internet-based cognitive behavioral therapy (iCBT) protocol and assess its efficacy on the modulation of ER and OCD severity. Specifically, the investigators will (1) examine to what extent the iCBT intervention modulates ER and the associated neurobiological mechanisms and (2) identify candidate biomarkers of successful treatment response.

Who May Be Eligible (Plain English)

Who May Qualify: - Primary diagnosis of current OCD according to the fifth Diagnostic and Statistical Manual of Mental Disorders - YBOCS score ≥ 16 - Psychotropic medication, if stable for at least 2 months prior to inclusion and if the dosage is maintained thoughout the study - Have the resources to access the online intervention (internet access; computer or tablet) Who Should NOT Join This Trial: - MRI contraindications - Prior medical history of neurological disorders or traumatic brain injury - Having performed CBT treatment for OCD in the last 2 years - Undergoing any psychological treatment - Suicidal ideation - Current alcohol or drug abuse Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Primary diagnosis of current OCD according to the fifth Diagnostic and Statistical Manual of Mental Disorders * YBOCS score ≥ 16 * Psychotropic medication, if stable for at least 2 months prior to inclusion and if the dosage is maintained thoughout the study * Have the resources to access the online intervention (internet access; computer or tablet) Exclusion Criteria: * MRI contraindications * Prior medical history of neurological disorders or traumatic brain injury * Having performed CBT treatment for OCD in the last 2 years * Undergoing any psychological treatment * Suicidal ideation * Current alcohol or drug abuse

Treatments Being Tested

BEHAVIORAL

ICBT

The intervention will consist in a structured internet-based intervention with 10 modules that will combine cognitive-behavioral techniques to improve obsessive-compulsive symptoms as well as the emotion regulation ability.

Locations (1)

Life and Health Sciences Research Institute, School of Medicine, University of Minho
Braga, Gualtar, Portugal