Responding With Evidence and Access for Childhood Headaches

Who May Qualify: - Diagnosis: Migraine with or without aura that meets the International Classification of Headache Disorders (ICHD) criteria 5 or presentation of continuous headache that includes migranous episodes based upon headache history obtained by site PI or designee. (includes presentation with or without medication overuse headache as well) - Headache Frequency: 4 or more headache days based upon prospective headache diary of 28 days prior to randomization - Amitriptyline Eligible: Site PI or medical staff determined participant to be eligible for clinical prescription of amitriptyline as a preventive treatment for migraine - English fluency: Able to complete the study visits and questionnaires in English Who Should NOT Join This Trial: - Current treatment includes amitriptyline and/or CBT specific to headache care - Current prescribed preventive antimigraine medication within a period equivalent to \< 5 half-lives of that medication before entering the baseline phase - Current treatment with onabotulinumtoxinA (Botox) or CGRP-based monoclonal antibody medications for migraine prevention - Youth who are pregnant - Report of current or ongoing suicidal thoughts. Suicide attempt within the past six months. History of bipolar disorder, prolonged QT, or pre-existing significant constipation or gastroparesis - Any and all other diagnoses or conditions which, in the opinion of the site investigator, would prevent the patient from being a suitable candidate for the study or interfere with the medical care needs of the participant Always talk to your doctor about whether this trial is right for you.