RECRUITINGOBSERVATIONAL
Effect of Sulthiame on EEG in Childhood Epilepsy Syndromes
Treatment of Epilepsy Syndromes of Childhood With Sleep Activation Using Sulthiame: an Exploratory Study of the Short Term Effect on EEG
About This Trial
The effect of sulthiame on EEG has been studied in epilepsy syndromes of childhood with sleep activation by comparing sleep EEG obtained at baseline and after 4 weeks of treatment. The aim of the study is to know if an effect is still identifiable after 2 weeks of treatment by performing sleep EEG recordings after 2 and 4 weeks of treatment, respectively.
Who May Be Eligible (Plain English)
Who May Qualify:
- Diagnosis of epilepsy syndromes of childhood with sleep activation
- Failure of at least two anti-epileptic drugs (AED)
- Sleep EEG performed in the last 7 days before inclusion and showing interictal epileptiform discharges (baseline EEG)
Who Should NOT Join This Trial:
- Previous trial with sulthiame
- More than 2 AED at inclusion
- Use of corticosteroids at inclusion
- Change in the anti-epileptic treatment in the 7 days before baseline EEG
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* Diagnosis of epilepsy syndromes of childhood with sleep activation
* Failure of at least two anti-epileptic drugs (AED)
* Sleep EEG performed in the last 7 days before inclusion and showing interictal epileptiform discharges (baseline EEG)
Exclusion Criteria:
* Previous trial with sulthiame
* More than 2 AED at inclusion
* Use of corticosteroids at inclusion
* Change in the anti-epileptic treatment in the 7 days before baseline EEG
Treatments Being Tested
DRUG
Sulthiame
Sulthiame add-on according to good clinical practice in these childhood epilepsy syndromes
Locations (3)
Angers University Hospital, Pediatric department
Angers, France
Strasbourg University Hospital, Pediatric department
Strasbourg, France
Toulouse University Hospital, Pediatric Neurology Department
Toulouse, France