RECRUITINGOBSERVATIONAL
Vascular MRI Evaluation in Giant Cell Arteritis (VEGA)
A Longitudinal Study of Orbital and Cranial Vessel Wall MRI in Giant Cell Arteritis by the Vascular MRI Evaluation in Giant Cell Arteritis (VEGA) Collaborative
About This Trial
The research study is being conducted to determine the utility of magnetic resonance imaging (MRI) in identifying inflammation of arteries supplying blood to the head, brain, and eyes. The target population includes patient with suspected giant cell arteritis (GCA; temporal arteritis).
Who May Be Eligible (Plain English)
Who May Qualify:
- Age 50 years or older
- First presentation of suspected GCA
- New or worsening cranial manifestations within 4 weeks of enrollment concerning for active GCA
- Elevated CRP greater than 1.0 mg/dl
- Plan to undergo temporal artery biopsy or ultrasound for diagnosis
Who Should NOT Join This Trial:
- Contra-indication to receiving MRI including:
Implanted medical devices, pacemaker, and metallic foreign fragments inside body/orbits Known gadolinium allergy Women who are pregnant or nursing
- Absence of cranial symptoms related to GCA (e.g., only large vessel GCA)
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* Age 50 years or older
* First presentation of suspected GCA
* New or worsening cranial manifestations within 4 weeks of enrollment concerning for active GCA
* Elevated CRP greater than 1.0 mg/dl
* Plan to undergo temporal artery biopsy or ultrasound for diagnosis
Exclusion Criteria:
* Contra-indication to receiving MRI including:
Implanted medical devices, pacemaker, and metallic foreign fragments inside body/orbits Known gadolinium allergy Women who are pregnant or nursing
* Absence of cranial symptoms related to GCA (e.g., only large vessel GCA)
Treatments Being Tested
DIAGNOSTIC_TEST
Magnetic Resonance Imaging (MRI)
Combined orbital and cranial vessel wall MRI
Locations (4)
Mayo Building and Gonda Building
Rochester, Minnesota, United States
3400 Civic Center Blvd
Philadelphia, Pennsylvania, United States
St. Joseph's Healthcare Hamilton
Hamilton, Ontario, Canada
University Hospital Wuerzburg
Würzburg, Würzburg, Germany