RECRUITINGINTERVENTIONAL

Breathing Training and Exercise Capacity in Non-CFB

Home-based, Digitally Delivered Breathing Training in People With Non-cystic Fibrosis Bronchiectasis: A Randomized Control Trial

About This Trial

The purpose of this research is to investigate whether a home-based and health coach supported specific breathing and respiratory muscle training program improves the ability to exercise, the function of the lungs and breathing muscles, and general clinical status in people with non-cystic fibrosis bronchiectasis (non-CFB).

Who May Be Eligible (Plain English)

Who May Qualify: - Mayo Clinic patient with confirmed diagnosis of Non-Cystic Fibrosis Bronchiectasis (non-CFB): Non-CFB as confirmed by clinical history, including cough, shortness of breath, exertional dyspnea, pulmonary function tests, and high-resolution computed tomography. Patients will be considered clinically stable if there is no evidence of an exacerbation or change(s) in medical therapy in the previous three weeks. - Able and willing to provide willing to sign a consent form to participate in the study. Who Should NOT Join This Trial: - Presence of significant coexisting disease, neurological conditions, and/or orthopedic complications that affect ability to undertake exercise. - Presence of advanced heart failure. - Current use of antibiotics. - Acute exacerbation(s) within 3-weeks prior to study commencement. - Participation within a pulmonary rehabilitation program within 6-months prior to study commencement. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria: * Mayo Clinic patient with confirmed diagnosis of Non-Cystic Fibrosis Bronchiectasis (non-CFB): Non-CFB as confirmed by clinical history, including cough, shortness of breath, exertional dyspnea, pulmonary function tests, and high-resolution computed tomography. Patients will be considered clinically stable if there is no evidence of an exacerbation or change(s) in medical therapy in the previous three weeks. * Able and willing to provide informed consent to participate in the study. Exclusion Criteria: * Presence of significant coexisting disease, neurological conditions, and/or orthopedic complications that affect ability to undertake exercise. * Presence of advanced heart failure. * Current use of antibiotics. * Acute exacerbation(s) within 3-weeks prior to study commencement. * Participation within a pulmonary rehabilitation program within 6-months prior to study commencement.

Treatments Being Tested

DEVICE

LungTrainers

A training device that provides a variable resistance against which users breathe out. Users breathe through a plastic mouthpiece that is connected to an acrylic cylinder via rubber tubing. The mouthpiece has several small holes of various diameters and up to three stainless steel weights (half-weight increments) can be inserted into the acrylic tube. With each breath-out, the user exhales against the resistance provided by the weight inserts, and each inspiration (i.e., breath-in) is unresisted. During each resisted exhalation, the weight inserts are 'lifted' within the acrylic tube depending on the level of expiratory pressure generated by the participant.

BEHAVIORAL

LungTrainers Pulmonary Rehabilitation regime

Series of different exercises using the LungTrainers device 3-5 days per week for approximately 10 weeks. Exercises complete in one long session (20-30 minutes) or be broken down into multiple shorter sessions (e.g., 3 x 10 minutes). A health coach will be assigned to guide participants through the LT-PR program.

Locations (1)

Mayo Clinic Florida

Jacksonville, Florida, United States