RECRUITINGINTERVENTIONAL

Promoting Early Intervention Timing and Attention to Language

About This Trial

The proposed study (PETAL: Promoting Early intervention Timing and Attention to Language) aims to determine the timing of intervention among infants with Increased Likelihood for Autism (ILA; at risk for autism by virtue of having an older sibling with autism) on communication and language outcomes at 24 months. Results of this study will determine when (9 vs 12 vs 15 months), and based on which measures (brain, language, or their combination) to augment parental support with a specialized parent-mediated coaching intervention for optimal outcomes on communication and language at 24 months. Children will be recruited at 6-8 months of age and will begin with entry assessments. All children will first begin with the MONITOR condition (using Ages \& Stages Questionnaire (ASQ-3) and activity cards. Then when the child is 9 months, they will be randomized to continue with MONITOR condition or COACH condition (i.e. JASPER Babble) after second set of assessments. There are a total of 6 assessment timepoints (6-8 months of age, 9 months of age, 12 months of age, 15 months of age, 18 months of age, and 24 months of age). At time points of 9months and 12 months, the child will be randomized to COACH or MONITOR conditions. Once the child is randomized to COACH condition, they will continue with that condition until they terminate the study at 24 months. At the 15 months timepoint, there will no longer be a randomization. Children that were in the MONITOR condition will change to the COACH condition until they terminate the study.

Who May Be Eligible (Plain English)

Who May Qualify: - This study will recruit approximately 140 infants ages 6-8 months of age who are younger siblings of children with ASD. - Both males and females are eligible for study participation and will be recruited. - Family income is under the very low income described under the Department of Housing and Community DevelopmentDivision of Housing Policy Agreement for the city of Los Angeles. Who Should NOT Join This Trial: - Infants who have seizures and are not stable on anti-seizure medication - Infant is expected to have surgery over the next year - Infant has associated physical disorders, and/or co-morbid with other syndromes or diseases. - All of the children will be free of additional sensory or motor impairments (e.g., Visual or hearing impairment) and othergenetic syndromes (e.g., Down Syndrome). - In addition, infants who are premature or less than 34 weeks (gestational age \<34 weeks) will be excluded. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria: * This study will recruit approximately 140 infants ages 6-8 months of age who are younger siblings of children with ASD. * Both males and females are eligible for study participation and will be recruited. * Family income is under the very low income described under the Department of Housing and Community DevelopmentDivision of Housing Policy Agreement for the city of Los Angeles. Exclusion Criteria: * Infants who have seizures and are not stable on anti-seizure medication * Infant is expected to have surgery over the next year * Infant has associated physical disorders, and/or co-morbid with other syndromes or diseases. * All of the children will be free of additional sensory or motor impairments (e.g., Visual or hearing impairment) and othergenetic syndromes (e.g., Down Syndrome). * In addition, infants who are premature or less than 34 weeks (gestational age \<34 weeks) will be excluded.

Treatments Being Tested

BEHAVIORAL

JASPER Babble

JASPER Babble is an evidence based early intervention that focuses on the core social communication and engagement skills of young children that are important to improvements in communication and language.

Locations (2)

UCLA

Los Angeles, California, United States

University of Massachusetts Medical Center

Worcester, Massachusetts, United States