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RECRUITINGOBSERVATIONAL

Cerebral and Cognitive Markers of Treatment Resistance in Obsessive Compulsive Disorder

Cerebral and Cognitive Markers of Treatment Resistance in Obsessive-compulsive Disorder: Towards Personalization of Patient Care

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

This study aims to define individual profiles of treatment resistants in order to find indicators and predictors of the therapeutic response.

Who May Be Eligible (Plain English)

Who May Qualify: - Obsessive compulsive disorder diagnosed according to Diagnostic and Statistical Manual 5 criteria (patients will be included regardless of the severity and resistance of their pathology and their levels of executive functions) - Understand and accept the constraints of the study - Be a beneficiary or affiliated to a Health Insurance scheme Who Should NOT Join This Trial: - Present one of the diagnoses according to the criteria of the DSM 5: schizophrenic disorders, substance abuse or dependence to a substance according to the criteria of the M.I.N.I. version 5.0 (Sheehan et al., 1998) - Generalized anxiety disorder, social anxiety, nicotine dependence and history of a major depressive episode are not exclusion criteria according to the M.I.N.I. version 5.0 (Sheehan et al., 1998) - Have a serious intercurrent pathology - Being a pregnant woman - Being a woman of childbearing age without effective contraception. - Being hospitalized under duress or on an outpatient basis in a care program - Being under judicial protection (reinforced curatorship, guardianship) Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Obsessive compulsive disorder diagnosed according to Diagnostic and Statistical Manual 5 criteria (patients will be included regardless of the severity and resistance of their pathology and their levels of executive functions) * Understand and accept the constraints of the study * Be a beneficiary or affiliated to a Health Insurance scheme Exclusion Criteria: * Present one of the diagnoses according to the criteria of the DSM 5: schizophrenic disorders, substance abuse or dependence to a substance according to the criteria of the M.I.N.I. version 5.0 (Sheehan et al., 1998) * Generalized anxiety disorder, social anxiety, nicotine dependence and history of a major depressive episode are not exclusion criteria according to the M.I.N.I. version 5.0 (Sheehan et al., 1998) * Have a serious intercurrent pathology * Being a pregnant woman * Being a woman of childbearing age without effective contraception. * Being hospitalized under duress or on an outpatient basis in a care program * Being under judicial protection (reinforced curatorship, guardianship)

Treatments Being Tested

OTHER

Functional MRI

Three cognitive tests will be performed in the MRI, namely a stroop task, an N-back task and a switching task

Locations (1)

Centre Hospitalier Henri Laborit
Poitiers, France