RECRUITINGOBSERVATIONAL
Cerebral and Cognitive Markers of Treatment Resistance in Obsessive Compulsive Disorder
Cerebral and Cognitive Markers of Treatment Resistance in Obsessive-compulsive Disorder: Towards Personalization of Patient Care
About This Trial
This study aims to define individual profiles of treatment resistants in order to find indicators and predictors of the therapeutic response.
Who May Be Eligible (Plain English)
Who May Qualify:
- Obsessive compulsive disorder diagnosed according to Diagnostic and Statistical Manual 5 criteria (patients will be included regardless of the severity and resistance of their pathology and their levels of executive functions)
- Understand and accept the constraints of the study
- Be a beneficiary or affiliated to a Health Insurance scheme
Who Should NOT Join This Trial:
- Present one of the diagnoses according to the criteria of the DSM 5: schizophrenic disorders, substance abuse or dependence to a substance according to the criteria of the M.I.N.I. version 5.0 (Sheehan et al., 1998)
- Generalized anxiety disorder, social anxiety, nicotine dependence and history of a major depressive episode are not exclusion criteria according to the M.I.N.I. version 5.0 (Sheehan et al., 1998)
- Have a serious intercurrent pathology
- Being a pregnant woman
- Being a woman of childbearing age without effective contraception.
- Being hospitalized under duress or on an outpatient basis in a care program
- Being under judicial protection (reinforced curatorship, guardianship)
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* Obsessive compulsive disorder diagnosed according to Diagnostic and Statistical Manual 5 criteria (patients will be included regardless of the severity and resistance of their pathology and their levels of executive functions)
* Understand and accept the constraints of the study
* Be a beneficiary or affiliated to a Health Insurance scheme
Exclusion Criteria:
* Present one of the diagnoses according to the criteria of the DSM 5: schizophrenic disorders, substance abuse or dependence to a substance according to the criteria of the M.I.N.I. version 5.0 (Sheehan et al., 1998)
* Generalized anxiety disorder, social anxiety, nicotine dependence and history of a major depressive episode are not exclusion criteria according to the M.I.N.I. version 5.0 (Sheehan et al., 1998)
* Have a serious intercurrent pathology
* Being a pregnant woman
* Being a woman of childbearing age without effective contraception.
* Being hospitalized under duress or on an outpatient basis in a care program
* Being under judicial protection (reinforced curatorship, guardianship)
Treatments Being Tested
OTHER
Functional MRI
Three cognitive tests will be performed in the MRI, namely a stroop task, an N-back task and a switching task
Locations (1)
Centre Hospitalier Henri Laborit
Poitiers, France