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RECRUITINGINTERVENTIONAL

South Africa Smoking Cessation and Engagement in HIV/TB Care Care

Treatment Development for Smoking Cessation and Engagement in HIV/TB

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The purpose of this study is to integrate elements from existing interventions developed by our team into a single intervention (QUIT-AD), designed to improve smoking cessation and favorable HIV/TB treatment outcomes among individuals with HIV and/or TB in Cape Town, South Africa. If feasibility, acceptability, and preliminary efficacy are demonstrated, the intervention will be ready for large-scale effectiveness/implementation testing. This program will has the potential to dramatically improve public health by increasing the smoking quit rate and facilitating favorable HIV/TB treatment outcomes among patients with HIV and/or TB in resource limited South African settings.

Who May Be Eligible (Plain English)

Who May Qualify: 1. Aged 18 or older 2. Willing and able to provide written willing to sign a consent form 3. Living with HIV, confirmed via medical record, and on antiretroviral therapy (ART) AND/OR within 1 month of initiating or reinitiating TB treatment; positive GeneXpert test or sputum culture (5) Daily smoker operationalized as \> 5 cigarettes per day, (6) Motivation (\> 5/10) to quit smoking or \> 24 hour quit past yr Who Should NOT Join This Trial: 1. Habitual use of other tobacco products 2. Current interfering untreated/unstable mental health condition (e.g., psychosis, bipolar dx) 3. Current use of non-study pharmacotherapy for smoking cessation, 4. Cognitive Behavioral Therapy for smoking cessation initiated within the past year, 5. Diagnosed with extra-pulmonary or drug resistant (MDR or XDR) TB based upon chart review Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: 1. Aged 18 or older 2. Willing and able to provide written informed consent 3. Living with HIV, confirmed via medical record, and on antiretroviral therapy (ART) AND/OR within 1 month of initiating or reinitiating TB treatment; positive GeneXpert test or sputum culture (5) Daily smoker operationalized as \> 5 cigarettes per day, (6) Motivation (\> 5/10) to quit smoking or \> 24 hour quit past yr Exclusion Criteria: 1. Habitual use of other tobacco products 2. Current interfering untreated/unstable mental health condition (e.g., psychosis, bipolar dx) 3. Current use of non-study pharmacotherapy for smoking cessation, 4. Cognitive Behavioral Therapy for smoking cessation initiated within the past year, 5. Diagnosed with extra-pulmonary or drug resistant (MDR or XDR) TB based upon chart review

Treatments Being Tested

BEHAVIORAL

QUIT-AD

An adapted, six-session cognitive behavioral therapy intervention for smoking cessation and treatment adherence

OTHER

Enhanced Treatment as Usual

Standard treatment for HIV/TB with one session of psychoeducation.

Locations (1)

University of Cape Town
Rondebosch, South Africa