RECRUITINGOBSERVATIONAL
Study of the Role of Genetic Modifiers in Hemoglobinopathies
About This Trial
This study will investigate the role of genetic modifiers in hemoglobinopathies through a large-scale, multi-ethnic genome-wide association study (GWAS).
Who May Be Eligible (Plain English)
Who May Qualify:
- Clinical diagnosis of an inherited hemoglobinopathy, including sickle cell disease (SCD), β-thalassemia, and α-thalassemia; all genotypes will be considered.
- Age ≥ 2 years old at the time of the collection of the phenotypic data.
- There will be no limits on study participants in terms of gender, ethnicity, morbidities.
Who Should NOT Join This Trial:
- Patients treated with stem cell transplantation or genetic therapy.
- Age \< 2 years old at the time of the collection of the phenotypic data.
- Patient or legal representative for minors unwilling or unable to give consent.
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* Clinical diagnosis of an inherited hemoglobinopathy, including sickle cell disease (SCD), β-thalassemia, and α-thalassemia; all genotypes will be considered.
* Age ≥ 2 years old at the time of the collection of the phenotypic data.
* There will be no limits on study participants in terms of gender, ethnicity, morbidities.
Exclusion Criteria:
* Patients treated with stem cell transplantation or genetic therapy.
* Age \< 2 years old at the time of the collection of the phenotypic data.
* Patient or legal representative for minors unwilling or unable to give consent.
Treatments Being Tested
GENETIC
GWAS
The study will perform a GWAS experiments for all recruited subjects. The blood sample will be collected during routine clinical visits, only if DNA is not already available in existing biobanks. All individuals will provide consent for participation in the study.
Locations (20)
Boston Children's Hospital
Boston, Massachusetts, United States
Lucrecia Paím Maternity
Luanda, Angola
University of Buenos Aires
Buenos Aires, Argentina
University Hospitals Leuven
Leuven, Belgium
Universiti Brunei Darussalam
Brunei, Brunei
Larnaca General Hospital
Larnaca, Cyprus
Limassol General Hospital
Limassol, Cyprus
Archbishop Makarios III Hospital
Nicosia, Cyprus
Paphos General Hospital
Paphos, Cyprus
Centre Hospitalier Monkole
Kinshasa, Democratic Republic of the Congo
Rigshospitalet
Copenhagen, Denmark
Hippokrateio Hospital of Athens
Athens, Greece
Laiko General Hospital
Athens, Greece
National and Kapodistrian University of Athens
Athens, Greece
General Hospital of Larissa
Larissa, Greece
Emek Medical Centre
Afula, Israel
University of Turin
Turin, Italy
Ampang Hospital
Ampang, Malaysia
Universiti Kebangsaan Malaysia
Bangi, Malaysia
Universiti Sains Malaysia
Kota Bharu, Malaysia