Combination of Diet and Oral Budesonide for Ulcerative Colitis
Remission With Diet for Ulcerative Colitis Exacerbations: A Single Blinded, International Randomized Controlled Clinical and Translational Trial
About This Trial
The ReDUCE Trial is a multinational single-blinded randomized controlled trial in mild to moderate flare of Ulcerative colitis (UC) disease patients. The purpose of the study is to validate the clinical efficacy of the UCED (Ulcerative colitis Exclusion Diet) with partial enteral nutrition (PEN) using a novel formula. The investigators anticipate that adding a novel specifically designed dietary intervention in addition to drug will lead to superior remission and mucosal healing via changes in the microbiome.
Who May Be Eligible (Plain English)
Original Eligibility Criteria
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Treatments Being Tested
Ulcerative colitis Exclusion Diet
a limited whole food diet (UCED)
Partial enteral nutrition (PEN)
The diet will be supplemented by 3 glasses a day (750 m"l) of the formula developed for UC using the UCED principles.
free diet
oral Budeosnide for 6 weeks + free diet
Oral Budesonide
Oral Budesonide 9 mg