Pre-Habilitation with Mindfulness and Exercise for Patients Undergoing Radical Cystectomy (PRIMER Trial)

Who May Qualify: - Provision of signed and dated willing to sign a consent form form - Stated willingness to comply with all study procedures and availability for the duration of the study - Male or female, aged ≥18 years of age - Good surgical candidate determined by treating surgeon - Histologically documented muscle invasive urothelial carcinoma of the bladder, high-risk non-muscle invasive bladder cancer, non-muscle invasive bladder cancer refractory to BCG, cisplatin ineligible muscle invasive bladder cancer receiving upfront cystectomy, urothelial carcinoma of the bladder with variant histology - your organs (liver, kidneys, etc.) are working well enough based on blood tests per protocol definition - ECOG performance status ≤2 - Received medical clearance to complete cardiopulmonary exercise testing - Willing to use the personal or study provided devices for monitoring and performing the exercise routines. - Fluent in English or Spanish for the EORTC QLQ questionnaire - No known contraindications to high intensity exercise Who Should NOT Join This Trial: - Contraindications to participating in aerobic exercise - Currently participating in an aerobic exercise program - New onset chest pain nor dyspnea with exertion - Histologically documented micropapillary or sarcomatoid bladder cancer - Distant metastatic carcinoma Always talk to your doctor about whether this trial is right for you.