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RECRUITINGOBSERVATIONAL

Acute Myeloid Leukemia At Initial Diagnosis and/or Relapse in Children, Teenagers and Young Adults: Molecular Profiling, Multidrug Testing and MSC Interaction Studies

Acute Myeloid Leukemia At Initial Diagnosis and/or Relapse in Children, Teenagers and Young Adults: Molecular Profiling, Multidrug Testing and MSC Interaction Studies - ALARM3

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Pediatric acute myeloid leukemias are disease with poor prognosis (overall survival of 60-75%) and high relapse rate of 35-45% require further understanding of the underlying biological mechanisms. The main objective of this study is to establish a biological collection to evaluate the genomic profiling of leukemic cells from primary blasts at diagnosis and/or relapse to improve identification of the main genetic hits involved in resistance and could predict a high risk of relapse. Other objectives include the study of bone marrow mesenchymal stem cells and ex vivo drug testing.

Who May Be Eligible (Plain English)

Who May Qualify: - 0-25 years old - Newly diagnosed de novo or secondary Acute Myeloid Leukemia (AML) or - Relapsed or refractory AML or - Patients with genetic predisposition to develop AML or - Patients without haematological malignancy nor AML genetic predisposition syndrome who undergo bone marrow aspirate as part of standard of care - Signed willing to sign a consent form of parents for patients aged less than 18 years old or signed willing to sign a consent form of the patient for patients aged 18 and over. Who Should NOT Join This Trial: - Refuse to participate - Chronic myeloid leukemia (CML) - Lack of health insurance (French social security) - Under protection (tutelle, curatelle or sauvegarde de justice) - Pregnancy or breastfeeding Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * 0-25 years old * Newly diagnosed de novo or secondary Acute Myeloid Leukemia (AML) or * Relapsed or refractory AML or * Patients with genetic predisposition to develop AML or * Patients without haematological malignancy nor AML genetic predisposition syndrome who undergo bone marrow aspirate as part of standard of care * Signed informed consent of parents for patients aged less than 18 years old or signed informed consent of the patient for patients aged 18 and over. Exclusion Criteria: * Refuse to participate * Chronic myeloid leukemia (CML) * Lack of health insurance (French social security) * Under protection (tutelle, curatelle or sauvegarde de justice) * Pregnancy or breastfeeding

Treatments Being Tested

OTHER

Collection of blood sample of bone marrow (cohort 1)

* 3 additional tubes of blood sample (cohort 1), at diagnosis and upon relapse if relapse occurs * Bone marrow aspirate : 3 additional tubes (cohort 1), at diagnosis and upon relapse if relapse occurs

OTHER

Collection of blood sample of bone marrow (cohort 2 and 3)

* 1 additional tube of blood sample (cohort 2 and 3 at inclusion) * Bone marrow aspirate: 1 additional tube (cohort 2 and 3 at inclusion)

Locations (20)

CHU Amiens Picardie site Sud
Amiens, France
CHU Angers
Angers, France
Hopital Minjoz
Besançon, France
CHU Pellegrin
Bordeaux, France
CHRU Morvan
Brest, France
CHU Caen
Caen, France
CHU Estaing
Clermont-Ferrand, France
CHU Francois Mitterand
Dijon, France
CHU Grenoble
Grenoble, France
CHU de la Réunion
La Réunion, France
Hopital Jeanne de Flandre - CHRU
Lille, France
CHU Limoges
Limoges, France
HCL Lyon
Lyon, France
Hôpital d'Enfants de la Timone
Marseille, France
CHU Montpellier
Montpellier, France
CHRU Nancy- Hopitaux de Brabois
Nancy, France
CHU Nantes
Nantes, France
CHU Nice
Nice, France
Hopital Robert Debré
Paris, France
Hopital Trousseau
Paris, France