RECRUITINGINTERVENTIONAL
High- Versus Low-calcium Water for Bone Health
Metabolic Response to the Consumption of Waters With Different Calcium Content: a Cross-over Clinical Study
About This Trial
The experimental study investigates which metabolic responses of calcium and parathyroid hormone are observable in blood and urine in a cohort of 41 healthy adults following a sequence of different exposures: low-calcium water first and high-calcium water afterward.
Who May Be Eligible (Plain English)
Who May Qualify:
- Body mass index ≥ 18 and \< 30
- Maintenance of diet and physical activity lifestyle throughout the duration of the study
- Acceptance of willing to sign a consent form
Who Should NOT Join This Trial:
- Consumption of water with calcium \> 150 mg/L
- Pregnancy (as established by self-declaration), breastfeeding, menopause
- Inability to follow the study protocol
- Cardiac, vascular, renal, and oncological disease
- Neuropsychiatric disease, developmental disorders
- Disease or past surgery affecting the gastrointestinal tract
- Drugs that interfere with bone (e.g. corticosteroids) or with fluid balance (e.g. diuretics)
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* Body mass index ≥ 18 and \< 30
* Maintenance of diet and physical activity lifestyle throughout the duration of the study
* Acceptance of informed consent
Exclusion Criteria:
* Consumption of water with calcium \> 150 mg/L
* Pregnancy (as established by self-declaration), breastfeeding, menopause
* Inability to follow the study protocol
* Cardiac, vascular, renal, and oncological disease
* Neuropsychiatric disease, developmental disorders
* Disease or past surgery affecting the gastrointestinal tract
* Drugs that interfere with bone (e.g. corticosteroids) or with fluid balance (e.g. diuretics)
Treatments Being Tested
OTHER
Loading of low-calcium water first, then high-calcium water
All cohort subjects are asked to consume water with less than 5 mg/L of calcium first, then are asked to consume water with at least 400 mg/L of calcium
Locations (1)
IRCCS Istituto Ortopedico Galeazzi
Milan, Italy