Investigation and Modulation of the Central Mu-Opioid Mechanism in Migraine (in Vivo)

Who May Qualify: - Male or female, aged 18 to 65 (inclusive) - Patients must have Episodic migraines that started before the age of 50, and currently experience: - Chronic migraine (ICHD-3-beta), headache occurring on 15 days/month for more than six months, which, on at least eight days/month, has the features of a migraine headache. - Episodic migraine (low frequency), specifically those with headache occurring less than 8 days/month. - Willing to limit the introduction of new treatments and medications during the study period. Who Should NOT Join This Trial: - Significantly greater pain in body sites other than the head - Active, untreated major concurrent systemic illness other than migraine - Medical conditions that can impair health status independent of migraine (including cardiopulmonary disorders, malignancy, uncontrolled endocrine or allergies) - Systemic rheumatic disorders (i.e., rheumatoid arthritis, systemic lupus erythematosus, gout, and fibromyalgia); - History or current evidence of a psychotic disorder (e.g., bipolar disorder, schizophrenia) or severe major depression, as evidenced by Beck Depression score of \>30\* - History of neurological disorder (e.g., epilepsy, stroke, neuropathy, neuropathic pain) - Medication overuse headache (ICHD-3), regular intake for ≥10 days per month of ergotamine, triptans, combination analgesics, or any combination thereof OR ≥15 days per month of simple analgesics (acetaminophen, aspirin, NSAID), for more than 3 months - Current use of opioid or dopaminergic drugs (or use within the last 3 months) or substance abuse (self-reported) - Drug test positive for opioid or recreational drug (e.g., cannabis) at the time of the PET scan visits - Allergic response to study radiotracers or chemically related drugs - Excluded by MRI Center or PET Center safety screening checklist (as administered by study staff) - Pregnant or lactating (negative urine pregnancy test must be available before any PET procedures are initiated) ...See full criteria on ClinicalTrials.gov Always talk to your doctor about whether this trial is right for you.