Alpha-synuclein Rt-quic and Neurologic Symptoms in Persons With idiOpathic anosMiA

Inclusion criteria with patients iOD: - Age 55 -75 years of age - Slowly progressing and non-fluctuating iOD - Able to give willing to sign a consent form and to cooperate as evaluated by the PI Exclusion criteria with patients iOD: - Diagnosed with a neurodegenerative disease or major neurological/psychiatric condition. - Anosmia/hyposmia caused by sino-nasal disease (including chronic rhinitis and allergy), after trauma, infection, congenial, olfactory dysfunction due to surgery, or toxins/drugs affecting the olfactory function. - Olfactory dysfunction with response to systemic or local corticosteroids if tried - Severe nasal cavity abnormalities or infections. - Overt signs of dementia or PD - Current alcohol or drug abuse - Terminal illness - Diagnosed with neurodegenerative disease or major neurological/psychiatric condition. Inclusion criteria controls: - Age 55 -75 years of age - Able to give willing to sign a consent form - Able to cooperate as evaluated by the PI Exclusion criteria controls: - Olfactory dysfunction on clinical test - Overt signs of dementia or PD - Severe nasal cavity abnormalities or infections. - Current alcohol or drug abuse - Diagnosed with neurodegenerative disease or major neurological/psychiatric condition. Always talk to your doctor about whether this trial is right for you.