Platelet-Directed Whole Blood Transfusion Strategy for Malaria

Who May Qualify: - Age \<5 years - Platelet count ≤75,000/uL - Hemoglobin \>5 and ≤9 g/dL - P. falciparum parasitemia ≥500 parasites/uL - Diagnosis of severe malaria meeting World Health Organization (WHO) criteria - Ability and willingness of the legal guardian to comply with study protocol for the duration of the study - Residence within health clinic catchment area - Signed willing to sign a consent form obtained from the parent or legal guardian of the participant Who Should NOT Join This Trial: - Residence in foster care or children otherwise under government supervision - Residence outside the hospital catchment area, or plan to leave the area - Presence of any other condition or abnormality which, in the opinion of the investigator, would compromise the safety of the participant or the quality of the data - Any contraindication to whole blood transfusion Always talk to your doctor about whether this trial is right for you.