Exogenous Ketone Esters for Drug Resistant Epilepsy

Who May Qualify: - Drug-resistant epilepsy - Seizure frequency ≥ 7 per week Who Should NOT Join This Trial: - Failure to obtain willing to sign a consent form - Recent intake of exogenous ketones, ketogenic diet, or any dietary restrictions/modifications - Severe disease conditions, including hepatic, renal, respiratory, cardiac, gastrointestinal, endocrinal, and immune systems - Hypo-/hyperglycemia - Metabolic acidosis - Ketosis (βHB \> 2 mmol/L) - GIT disorders, including gastritis/peptic ulcer, diarrhea/constipation, and irritable bowel disease - Malnutrition/obesity - Limitations to oral feeding (e.g., severe gastroesophageal reflux) - Inborn errors of metabolism - Chromosomal disorders - Surgically-remediable epilepsy - Allergies or any other contraindication to ketone supplements - Inapplicable recording of seizures - Incompliance to anti-seizure medications and/or irregular follow-up - Recent propofol therapy - Intake of carbonic-anhydrase inhibitors Always talk to your doctor about whether this trial is right for you.