RECRUITINGOBSERVATIONAL

Neurobiological Markers of Treatment Response for Anxiety and OCD

About This Trial

Obsessive-compulsive disorder (OCD) and anxiety disorders are common and debilitating conditions which are often chronic when treatment is not provided. International guidelines recommend cognitive behavioral therapy (CBT) as the first-line treatment, and research has shown that CBT can be delivered over a concentrated period of time. The Bergen 4-Day Treatment (B4DT) is an exposure-based treatment which is delivered over four consecutive days. B4DT has been shown to induce rapid and long-lasting remission in around 70% of patients. This provides a platform for studying psychological and neurobiological changes associated with treatment response and non-response. The present study will investigate longitudinal changes in psychological measures and DNA methylation in patients who receive the B4DT, as well as a subset will also undergo multimodal brain imaging.

Who May Be Eligible (Plain English)

Who May Qualify: - Diagnosed with obsessive-compulsive disorder, panic disorder or social anxiety disorder using DSM-5 criteria - Referred to National Clinic for 4-Day Treatment, Haukeland University Hospital, Bergen, Norway - Consented to participate in the "Kvalitetsregister for konsentrerte behandlingsformat" Who Should NOT Join This Trial: - Suicidal, ongoing mania, primary eating disorder, intellectual disability, ongoing psychosis, ongoing substance abuse For MRI substudy: Who May Qualify: \- For the healthy controls, no previous or current psychiatric disorders as detected by the Mini International Neuropsychiatric Interview (MINI) Who Should NOT Join This Trial: \- MRI incompatibility (e.g. pregnancy, metal implants) Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria: * Diagnosed with obsessive-compulsive disorder, panic disorder or social anxiety disorder using DSM-5 criteria * Referred to National Clinic for 4-Day Treatment, Haukeland University Hospital, Bergen, Norway * Consented to participate in the "Kvalitetsregister for konsentrerte behandlingsformat" Exclusion Criteria: * Suicidal, ongoing mania, primary eating disorder, intellectual disability, ongoing psychosis, ongoing substance abuse For MRI substudy: Inclusion Criteria: \- For the healthy controls, no previous or current psychiatric disorders as detected by the Mini International Neuropsychiatric Interview (MINI) Exclusion Criteria: \- MRI incompatibility (e.g. pregnancy, metal implants)

Treatments Being Tested

BEHAVIORAL

Bergen 4-Day Treatment (B4DT)

A concentrated and exposure-based psychological treatment over four consecutive days

Locations (1)

Bergen Center for Brain Plasticity

Bergen, Vestland, Norway