Skip to main content
TrialFinder
TrialFinder is for informational purposes only and does not provide medical advice. Always talk to your doctor about whether a trial is right for you.
RECRUITINGPhase 3INTERVENTIONAL

Aspirin for the Prevention of Preeclampsia and Pregnancy Outcomes After Assisted Reproductive Technology

Aspirin for the Prevention of Preeclampsia and Pregnancy Outcomes in Nulliparous Women After Assisted Reproductive Technology. APPART

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

This study seeks to validate the hypothesis that nulliparous pregnant women after Assisted Reproductive Technology (ART) are at high risk of preeclampsia and perinatal complications and represent a subgroup for which aspirin prophylaxis during pregnancy may be effective in the prevention of preterm preeclampsia and other perinatal adverse outcomes.

Who May Be Eligible (Plain English)

Who May Qualify: - Nulliparous women aged 18 years or more - Pregnancy following ART, including in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), oocyte donation or intrauterine insemination with sperm donor - Singleton pregnancy - Evolutive pregnancy between 9 and 14 weeks of gestation - Women affiliated to a French Social Security Insurance or equivalent social protection - Written willing to sign a consent form Who Should NOT Join This Trial: - Major fetal abnormality - Regular treatment with aspirin (including antiphospholipid syndrome) - Aspirin contraindications (allergy, von Willebrand disease, peptic ulceration, hemophilia) - Women protected by law. - Women included in another interventional study. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Nulliparous women aged 18 years or more * Pregnancy following ART, including in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), oocyte donation or intrauterine insemination with sperm donor * Singleton pregnancy * Evolutive pregnancy between 9 and 14 weeks of gestation * Women affiliated to a French Social Security Insurance or equivalent social protection * Written informed consent Exclusion Criteria: * Major fetal abnormality * Regular treatment with aspirin (including antiphospholipid syndrome) * Aspirin contraindications (allergy, von Willebrand disease, peptic ulceration, hemophilia) * Women protected by law. * Women included in another interventional study.

Treatments Being Tested

DRUG

Aspirin

Experimental drug administrated orally

DRUG

Placebo

Treatment for the control group

Locations (20)

CHU Angers
Angers, France
CHU Bordeaux
Bordeaux, France
CHU Clermont-Ferrand
Clermont-Ferrand, France
CHU Dijon-Bourgogne
Dijon, France
CHU Lille
Lille, France
HCL - Groupement Hospitalier Est, Hôpital Femme Mère Enfant
Lyon, France
AP-HM Hôpital de la Conception
Marseille, France
AP-HM Hôpital Nord
Marseille, France
CHU Montpellier
Montpellier, France
CHRU Nancy
Nancy, France
CHU Nantes
Nantes, France
CHU Nîmes
Nîmes, France
Groupe hospitalier St Joseph
Paris, France
Hôpital Armand - Trousseau
Paris, France
Hôpital Cochin
Paris, France
CHI Poissy Saint Germain en Laye
Poissy, France
CHU Poitiers
Poitiers, France
CHU Rennes
Rennes, France
CHU Saint Etienne, Hôpital Nord
Saint-Etienne, France
CHU Strasbourg
Strasbourg, France