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RECRUITINGOBSERVATIONAL

Quantifying Systemic Immunosuppression to Personalize Cancer Therapy

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The Serpentine (Stratify cancER PatiENTs by ImmuNosupprEssion) project, represents the most consistent effort so far attempted to translate MDSC into clinical practise by producing an off-the-shelf compliant assay for quantifying these cells in peripheral blood.

Who May Be Eligible (Plain English)

Inclusion Criteria - Histologically documented diagnosis of metastatic/locally advanced melanoma, hormone-refractory breast cancer, RCC and UC, SCCHN, SCC or NSCLC, stage III resectable NSCLC will also be included - Will and ability to comply with the protocol - Willingness and ability to provide an adequate archival Formalin-Fixed Paraffin-Embedded (FFPE) tumor sample available for exploratory biomarker analysis - Age from 18 to 90 years at the time of recruitment - ECOG Performance Status \<= 2 - Understanding and signature of the willing to sign a consent form - Consenting to participate to the socio-economical-psychological survey Exclusion Criteria - Known history of HIV infection - Serious neurological or psychiatric disorders - Pregnancy or lactation - Inability or unwillingness of participant to give written willing to sign a consent form - Inability or unwillingness to be regularly followed up at the same center Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria * Histologically documented diagnosis of metastatic/locally advanced melanoma, hormone-refractory breast cancer, RCC and UC, SCCHN, SCC or NSCLC, stage III resectable NSCLC will also be included * Will and ability to comply with the protocol * Willingness and ability to provide an adequate archival Formalin-Fixed Paraffin-Embedded (FFPE) tumor sample available for exploratory biomarker analysis * Age from 18 to 90 years at the time of recruitment * ECOG Performance Status \<= 2 * Understanding and signature of the informed consent * Consenting to participate to the socio-economical-psychological survey Exclusion Criteria * Known history of HIV infection * Serious neurological or psychiatric disorders * Pregnancy or lactation * Inability or unwillingness of participant to give written informed consent * Inability or unwillingness to be regularly followed up at the same center

Treatments Being Tested

OTHER

MDSC quantification

Blood sample will be collected at baseline and during therapy, and, optionally, in case of disease progression (PD).

Locations (1)

Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Italy