RECRUITINGINTERVENTIONAL

Determining the Role of Social Reward Learning in Social Anhedonia

Determining the Role of Social Reward Learning in Social Anhedonia in First-Episode Psychosis Using Motivational Interviewing in a Perturbation-Based Neuroimaging Approach

About This Trial

This is a clinical trial study that aims to evaluate the specificity of the relationship between reduced sensitivity to social reward and social anhedonia at both behavioral and neural levels. Individuals who recently experienced their first-episode psychosis will be recruited. Participants will be randomized 1:1 to motivational interviewing or a time- and format-matched control probe. At pre- and post-probe, participants will perform two social reward learning tasks in the scanner. With this design feature, we will examine the relationship between sensitivity to social reward and reduced subjective experience of social pleasure at both the behavioral and neural levels.

Who May Be Eligible (Plain English)

Who May Qualify: - Age 18-35 years - A first episode of a psychotic illness that began within the past three years - Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 diagnosis of schizophrenia, schizophreniform, or schizoaffective disorder - Taking 2nd generation antipsychotic medications - Estimated premorbid IQ not less than 70 as assessed with the Wechsler Test of Adult Reading - Appropriate for scanning (i.e., no pacemaker or metal implants) and expressed willingness to participate in scanning - Sufficient fluency in English to comprehend testing procedures - Corrected vision of at least 20/30 Who Should NOT Join This Trial: - No evidence that substance use makes the diagnosis ambiguous (rule out substance-induced psychosis) - No evidence of moderate or severe alcohol or substance use disorder in the past 3 months - No clinically significant disease based on medical history (e.g., epilepsy) or significant head injury - For females: no current pregnancy - No sedatives or anxiolytics on the day of assessment - No medication change 3 weeks prior to enrollment Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria: * Age 18-35 years * A first episode of a psychotic illness that began within the past three years * Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 diagnosis of schizophrenia, schizophreniform, or schizoaffective disorder * Taking 2nd generation antipsychotic medications * Estimated premorbid IQ not less than 70 as assessed with the Wechsler Test of Adult Reading * Appropriate for scanning (i.e., no pacemaker or metal implants) and expressed willingness to participate in scanning * Sufficient fluency in English to comprehend testing procedures * Corrected vision of at least 20/30 Exclusion Criteria: * No evidence that substance use makes the diagnosis ambiguous (rule out substance-induced psychosis) * No evidence of moderate or severe alcohol or substance use disorder in the past 3 months * No clinically significant disease based on medical history (e.g., epilepsy) or significant head injury * For females: no current pregnancy * No sedatives or anxiolytics on the day of assessment * No medication change 3 weeks prior to enrollment

Treatments Being Tested

BEHAVIORAL

Motivational Interviewing

Three motivational interviewing sessions will target sensitivity to social reward, including subjective evaluation of social interaction, socially rewarding stimuli, and events (e.g., interactions with others, feedback from others).

BEHAVIORAL

Nutrition Didactic Training

The Nutrition didactic training will ask participants to discuss pros and cons of healthy eating habits and how to improve their current eating habits.

Locations (2)

University of Alabama at Birmingham

Birmingham, Alabama, United States

University of California Los Angeles

Los Angeles, California, United States