Comparing Hand-sewn (END-TO-END or Kono-S) to Stapled Anastomosis in Ileocolic Resection for Crohn's Disease

Who May Qualify: - Males and females aged \>16 years - Ileocolic disease or disease of the neoterminal ileum with an indication for resection - Concurrent therapies with corticosteroids, 5-ASA drugs, thiopurines, MTX, antibiotics, and anti-TNF therapy are permitted. - All patients should have undergone a colonoscopy and a recent update of imaging (e.g. Ultrasound, MR enterography (or CT enterography if MR is contraindicated))- Ability to comply with protocol. - Competent and able to provide written willing to sign a consent form. - Patient must have been discussed in the local MDT Who Should NOT Join This Trial: - Inability to give willing to sign a consent form. - Patients less than 16 years of age. - Clinically significant medical conditions within the six months before the operation : e.g. myocardial infarction, active angina, congestive heart failure or other conditions that would, in the opinion of the investigators, compromise the safety of the patient. - History of cancer \< 5 years which might influence patients prognosis - Emergent operation. - Pregnant or breast feeding. - Inability to follow up at 3, 6 and 12 months for postoperative assessment, imaging and endoscopy. Always talk to your doctor about whether this trial is right for you.