Ketamine in OCD: Efficacy and Effects on Stress and Cognition

Who May Qualify: - Primary diagnosis of obsessive-compulsive disorder - A score of 16 or higher on the Yale-Brown Obsessive Compulsive Scale and ability to provide written willing to sign a consent form - At least one previous treatment for OCD Exclusion Criteria Experimental Group: - Any history of current or past psychotic disorder - A manic episode within the preceding three years - Current or unstable remitted substance abuse or dependence except nicotine - Pregnancy or elevated risk of becoming pregnant during study duration (desire to have children) and refusal to utilize a proper method of contraception - Any current severe personality disorder except comorbid anankastic personality disorder - Morbus Raynaud - Inability to follow the study protocol or adhere to operational requirements - Current and unstable suicidality - Unstable hypertension - Untreated hyperthyroidism - Any unstable cardiovascular disease - Untreated disorders severely affecting the HPA-axis (M.Addison, M.Cushing) - Current pharmacological therapy severely affecting the HPA-axis like corticosteroids or ACTH Exclusion Criteria Treatment as Usual Group: - Any history of current or past psychotic disorder - A manic episode within the preceding three years - Current or unstable remitted substance abuse or dependence except nicotine - Any current severe personality disorder except comorbid anankastic personality disorder - Current and unstable suicidality Always talk to your doctor about whether this trial is right for you.