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RECRUITINGOBSERVATIONAL

Characterization of Epithelial Ovarian Cancer Patients in Terms of Homologous Recombination Phenotype

Characterization of Epithelial Ovarian Cancer Patients in Terms of Homologous Recombination Phenotype - A Prospective Observational Study

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

This is a prospective observational multi-country, multi-center study of a large real-world cohort of first line (1L) epithelial ovarian cancer patients, exposed to standard of care (SOC) treatment stratified according to BRCA1/2 and HRD status.

Who May Be Eligible (Plain English)

Patients are eligible to be included in the study, if all the following inclusion criteria are met: - Patients with newly diagnosed diagnosed by tissue sample (biopsy-confirmed) epithelial ovarian cancer: - FIGO stage I-II with a known BRCA1/2 mutation (germline/gBRCA or somatic/tBRCA) - FIGO stage III-IV of any histology - Women aged ≥18 years of age at the time of diagnosis - Patients intended for platinum-based chemotherapy treatment - Patients capable of giving signed willing to sign a consent form, which includes compliance with the requirements and restrictions listed in the willing to sign a consent form form (ICF) and in this protocol - Patients consent to provide archival tumor tissue sample Patients are ineligible to be included in the study, if any of the exclusion criteria are met: - Non-epithelial ovarian cancer, borderline tumors, or mucinous histology - Patients with FIGO stage I-II, BRCAwt ovarian cancer Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Patients are eligible to be included in the study, if all the following inclusion criteria are met: * Patients with newly diagnosed histologically confirmed epithelial ovarian cancer: * FIGO stage I-II with a known BRCA1/2 mutation (germline/gBRCA or somatic/tBRCA) * FIGO stage III-IV of any histology * Women aged ≥18 years of age at the time of diagnosis * Patients intended for platinum-based chemotherapy treatment * Patients capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol * Patients consent to provide archival tumor tissue sample Patients are ineligible to be included in the study, if any of the exclusion criteria are met: * Non-epithelial ovarian cancer, borderline tumors, or mucinous histology * Patients with FIGO stage I-II, BRCAwt ovarian cancer

Treatments Being Tested

OTHER

Standard of care

Patients receive standard of care treatment according to local and national guidelines

Locations (1)

Rigshospitalet
København Ø, Region Sjælland, Denmark