RECRUITINGOBSERVATIONAL
Prospective Cohort of Patients With Systemic Sclerosis at Brest University Hospital With Biobanking
Prospective Cohort of Patients With Systemic Sclerosis at Brest University Hospital and Constitution of a Biobank
About This Trial
This study corresponds to a monocentric prospective cohort of adult patients with systemic sclerosis. It will allow the constitution of an organized collection of longitudinal clinical data as well as collection of biological samples, including blood samples, as well as stool sample and skin swab for microbiota analysis.
Who May Be Eligible (Plain English)
Who May Qualify:
- Major patient with systemic sclerosis defined according to the EULAR 2013 criteria (see Appendix 1)
- Patient evaluated within the framework of the reference center for rare autoimmune conditions (where your immune system attacks your own body)s of the CHU of Brest.
- Patient affiliated to the social security system
- Patient having signed a written willing to sign a consent form.
Who Should NOT Join This Trial:
- Minor
- Patient under legal protection (guardianship, curatorship)
- Refusal to participate
- Patient unable to consent
- Pregnant or breastfeeding woman
- Hemoglobin (Hb) level \< 7g/dl
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* Major patient with systemic sclerosis defined according to the EULAR 2013 criteria (see Appendix 1)
* Patient evaluated within the framework of the reference center for rare autoimmune diseases of the CHU of Brest.
* Patient affiliated to the social security system
* Patient having signed a written informed consent.
Exclusion Criteria:
* Minor
* Patient under legal protection (guardianship, curatorship)
* Refusal to participate
* Patient unable to consent
* Pregnant or breastfeeding woman
* Hemoglobin (Hb) level \< 7g/dl
Treatments Being Tested
OTHER
Blood samples
80 ml of blood samples collected at inclusion and at 18 months
OTHER
Stool samples
A stool sample for collection of digestive microbiota at inclusion
OTHER
Skin swab samples
A skin swab sample for collection of skin microbiota at inclusion and at 18 months
OTHER
Questionnaires on quality of life, pain and disability
At inclusion and each year for 5 years
OTHER
Skin biopsies
At inclusion and 18 months
Locations (1)
CHRU de Brest
Brest, France