Skip to main content
TrialFinder
TrialFinder is for informational purposes only and does not provide medical advice. Always talk to your doctor about whether a trial is right for you.
RECRUITINGINTERVENTIONAL

MiECC Versus Conventional Cardiopulmonary Bypass in Cardiac Surgery (MiECS)

Minimally Invasive Extracorporeal Circulation Versus Conventional Cardiopulmonary Bypass in Patients Undergoing Cardiac Surgery (MiECS): a Randomised Controlled Trial

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

MiECS is one of the largest multicentre randomised controlled trials on extracorporeal circulation conducted under the auspices of Minimal Invasive Extracorporeal Technologies International Society (MiECTiS). It is designed to ultimately address the emerging effectiveness of MiECC systems in the light of modern perfusion practice worldwide. The primary hypothesis is that MiECC, as compared to conventional CPB (cCPB), reduces the proportion of patients experiencing serious perfusion-related postoperative morbidity after cardiac surgery. The study will be led by the Clinical Research Unit of the Special Unit for Biomedical Research and Education (SUBRE), Aristotle University of Thessaloniki School of Medicine in Greece (AUSoM) with Chief Investigator Professor Kyriakos Anastasiadis, who is a key-opinion-leader in the field of MiECC, founder and Executive Board of MiECTiS.

Who May Be Eligible (Plain English)

Who May Qualify: - All patients undergoing any elective or urgent coronary artery bypass grafting (CABG), aortic valve replacement (AVR) or CABG+AVR surgery using extracorporeal circulation without circulatory arrest. Who Should NOT Join This Trial: - Requirement for emergency or salvage operation. - Requirement for major aortic surgery (e.g. aortic root replacement). - Contraindication or objection (e.g. Jehovah's Witnesses) to transfusion of blood products. - Congenital or acquired platelet, red cell or clotting disorders (patients with iron deficient anaemia will not be excluded). - Inability to give willing to sign a consent form for the study (e.g. learning or language difficulties). Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * All patients undergoing any elective or urgent coronary artery bypass grafting (CABG), aortic valve replacement (AVR) or CABG+AVR surgery using extracorporeal circulation without circulatory arrest. Exclusion Criteria: * Requirement for emergency or salvage operation. * Requirement for major aortic surgery (e.g. aortic root replacement). * Contraindication or objection (e.g. Jehovah's Witnesses) to transfusion of blood products. * Congenital or acquired platelet, red cell or clotting disorders (patients with iron deficient anaemia will not be excluded). * Inability to give informed consent for the study (e.g. learning or language difficulties).

Treatments Being Tested

DEVICE

Minimal Invasive Extracorporeal Circulation

Cardiac surgery with Minimal Invasive Extracorporeal Circulation (MiECC).

DEVICE

Conventional cardiopulmonary bypass

Cardiac surgery with conventional cardiopulmonary bypass (cCPB).

Locations (13)

Perfusion Services University Health Network, Toronto General Hospital
Toronto, Canada
Department of Cardiac Surgery
Coswig, Germany
Department of Thoracic and Cardiovascular Surgery, University Medical Centre Goettingen
Göttingen, Germany
Department of Cardiothoracic and Vascular Surgery, Ulm University Hospital
Ulm, Germany
Cardiothoracic Department AHEPA University Hospital
Thessaloniki, Greece
Department of Cardiac Surgery GVM Anthea Hospital
Bari, Italy
Department of Cardiac Surgery GVM Maria Eleonora Hospital
Palermo, Italy
Department of Cardiovascular Surgery, Ankara City Hospital
Ankara, Turkey (Türkiye)
Department of Cardiovascular Surgery, Izmir Bakırçay University, Faculty of Medicine
Izmir, Turkey (Türkiye)
Department of Cardiovascular Surgery, Faculty of Medicine, Recep Tayyip Erdoğan University
Rize, Turkey (Türkiye)
Department of Cardiac Surgery, Royal Papworth Hospital
Cambridge, United Kingdom
Deparment of Cardiac Surgery, Castle Hill Hospital
Hull, United Kingdom
Department of Cardiothoracic Surgery, Hammersmith Hospital
London, United Kingdom