Studies in Amyotrophic Lateral Sclerosis (ALS) and Other Neurodegenerative Motor Neuron Disorders

Inclusion Criteria ALS or Suspected ALS Patient - Clinical diagnosis of possible, laboratory-supported probable, probable or definite ALS according to modified EL Escorial criteria, suspected ALS according to original El Escorial criteria, or diagnosis of a neurodegenerative disorder with evidence of ALS plus extramotor features; OR - Blood relative (first, second or third degree) with history of ALS or neurodegenerative disorder with evidence of ALS plus extramotor features; OR: - A clinical suspicion or referral for ALS; - \> 18 years of age; - Willing and able to give signed willing to sign a consent form or assent that has been approved by the Institutional Review Board (IRB). Blood Relative of ALS Patient - Family history (first, second or third degree blood relative) of ALS or other motor neuron disease; - \> 18 years of age; - Willing and able to give signed willing to sign a consent form that has been approved by the Institutional Review Board (IRB). Healthy Control - No personal or family history (first, second or third degree blood relative) of ALS or other motor neuron disease; - \> 18 years of age; - No personal history of other neurodegenerative disease (i.e., Alzheimer disease, Parkinson disease); - Willing and able to give signed willing to sign a consent form that has been approved by the Institutional Review Board (IRB). Who Should NOT Join This Trial: ALS or Suspected Patient • Limited mental capacity rendering the subject unable to provide written willing to sign a consent form or assent or comply with standard phlebotomy procedures. Blood Relative of ALS Patient • Limited mental capacity rendering the subject unable to provide written willing to sign a consent form or comply with standard phlebotomy procedures. Healthy Control Subject - Personal or family history of dementia or other neurodegenerative disease (Parkinson disease, Alzheimer disease, etc.); ...See full criteria on ClinicalTrials.gov Always talk to your doctor about whether this trial is right for you.