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RECRUITINGOBSERVATIONAL

Taiwan Associated Genetic and Nongenetic Small Vessel Disease

Deciphering, Construction and Validation of Magnetic Resonance Imaging Maps, Clinical Features and Outcomes in Genetic and Nongenetic Cerebral Small Vessel Diseases

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The TAG-SVD enrolled patients with clinical and neuroimaging features of cerebral small vessel disease (CSVD). All enrolled patients will receive next-generation sequence (NGS) with probes designed to target five candidate CSVD genes, and patients will be divided into genetic or non-genetic groups accordingly. Their clinical features and outcome will be followed for at least 2 years.

Who May Be Eligible (Plain English)

Who May Qualify: Participants must have at least one of the following symptoms/signs or history - stroke (especially small vessel occlusion type of ischaemic stroke, spontaneous ICH or young stroke) - cognitive impairment or dementia - gait disturbance - parkinsonism (especially vascular parkinsonism features) - headache (especially migraine) - positive family history of hereditary CSVD - MRI evidence of CSVD (MRI may be done for other reasons), including mild to moderate white matter hyper intensity, any lacune, or any cerebral microbleed Who Should NOT Join This Trial: - MRI evidence of CSVD due to other inflammatory, malignancy, or structural lesions - patients or family members not willing to sign willing to sign a consent form Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: Participants must have at least one of the following symptoms/signs or history * stroke (especially small vessel occlusion type of ischaemic stroke, spontaneous ICH or young stroke) * cognitive impairment or dementia * gait disturbance * parkinsonism (especially vascular parkinsonism features) * headache (especially migraine) * positive family history of hereditary CSVD * MRI evidence of CSVD (MRI may be done for other reasons), including mild to moderate white matter hyper intensity, any lacune, or any cerebral microbleed Exclusion Criteria: * MRI evidence of CSVD due to other inflammatory, malignancy, or structural lesions * patients or family members not willing to sign informed consent

Treatments Being Tested

DIAGNOSTIC_TEST

MRI

Patients will repeat study-protocol MRI at baseline (enrollment) and at least once in 1 year or 2 years follow-up (depends on availability).

Locations (1)

Department of Neurology, National Taiwan University Hospital
Taipei, Taiwan