RECRUITINGOBSERVATIONAL
Disease Activity Biomarkers in Patients With Systemic Lupus Erythematosus
Disease Activity Biomarkers in Patients With Systemic Lupus Erythematosus. Recherche de Biomarqueurs de l'activité de la Maladie Chez Des Patients Atteints de Lupus érythémateux disséminé.
About This Trial
The aim of this research project is to better understand the origin and clinical significance of two lupus-specific "genetic signatures" (IFN signature and plasma cell signature) in patient subgroups with well-defined clinical characteristics. Our aim is to correlate these genetic signatures with cell activation profiles and the production of specific cytokines in different populations from whole blood and in short-term cultures of these circulating cells.
Who May Be Eligible (Plain English)
Who May Qualify:
- Fulfilment of the EULAR/ACR classification criteria of SLE.
- 18 years of age or above.
- Incident or Flare biopsy-proven proliferative or membranous LN
Who Should NOT Join This Trial:
- Antiphospholipid syndrome nephropathy (APSN).
- Pregnancy at baseline (pregnancy during follow-up will not lead to exclusion).
- Anticipated non-adherence to therapy.
- Medical conditions interfering with outcome evaluations.
- Inability to read and/or sign the willing to sign a consent form form.
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* Fulfilment of the EULAR/ACR classification criteria of SLE.
* 18 years of age or above.
* Incident or Flare biopsy-proven proliferative or membranous LN
Exclusion Criteria:
* Antiphospholipid syndrome nephropathy (APSN).
* Pregnancy at baseline (pregnancy during follow-up will not lead to exclusion).
* Anticipated non-adherence to therapy.
* Medical conditions interfering with outcome evaluations.
* Inability to read and/or sign the informed consent form.
Locations (1)
Cliniques universitaires Saint-Luc
Brussels, Belgium