Safety and Tolerability of Chlorquine in Addition to Anti-tuberculosis Therapy

Inclusion criteria: 1. Informed study-specific consent (including possible pharmacogenetic analysis) as documented by signature 2. Healthy volunteers aged between 18 and 50 years of age (significantly increased risk of side effects from 50 years of age with Rimstar®) Exclusion criteria: 1. Lack of highly effective contraception during the study treatment and for 8 months after the last dose of study treatment (until Day 254, visit 7) according to 11.4 with the following consideration for participating women: * From Day 1 (visit 2) up to Day 30 (visit 6) hormonal contraception is insufficient due to lower concentrations of estrogen and/or gestagen during and up to 14 days after Rimstar® intake. The hormonal contraception must be supplemented with a barrier method (preferably male condom). * From Day 30 (visit 6) up to Day 254 (visit 7) hormonal contraceptive methods can be used and are considered highly effective. 2. Pregnant or lactating females 3. Contraindications to the class of drugs under study, e.g. known hypersensitivity or allergy to class of drugs or the investigational product, glucose-6-phosphate dehydrogenase insufficiency (favism) 4. Regular treatment with drugs in the last 14 days prior to first intake of study drug (except for Paracetamol and Vitamin B6 (pyridoxine), see 8.7). 5. History of or concurrent, clinically significant cardiac, immunological, pulmonary, neurological, renal, gastrointestinal, dermatological, endocrinological or other major disease as determined by the Investigator and/or his representative 6. History of or presence of any clinically significant abnormality in vital signs, ECG, or laboratory test results or has any medical or psychiatric condition that, in the opinion of the Investigator, may interfere with the study procedures or compromise subject safety 7. History of or currently present retinopathy or other disturbances of the field of vision or the retina according to the Investigator 8. History of alcohol or substance abuse for the last 3 months prior to Screening, as determined by the Investigator 9. Weight less than 55kg 10. Intake of grapefruit juice or grapefruits within 2 weeks before the first study drug administration and during treatment phase 11. Donation of blood or blood products within a 30-day period prior to Screening 12. Current enrolment or a plan to enroll in any interventional clinical study in which an investigational treatment or approved therapy for investigational use is administered within 3 months of participation to the Clear trial. 13. Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant 14. The investigator, his/her family members, employees and other dependent persons