Skip to main content
TrialFinder
TrialFinder is for informational purposes only and does not provide medical advice. Always talk to your doctor about whether a trial is right for you.
RECRUITINGOBSERVATIONAL

UK Heart Failure With Preserved Ejection Fraction

UK Heart Failure With Preserved Ejection Fraction Registry

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Heart failure occurs when the heart is no longer able to pump blood around the body properly. It can cause breathlessness, swollen feet and ankles, and tiredness. In about half of patients with heart failure, one measure of the heart's pumping function, called the 'ejection fraction', is normal. This type of heart failure is called heart failure with preserved ejection fraction, or HFpEF. HFpEF remains poorly understood. It is not clear why some people develop HFpEF, or what determines the severity of the condition. Treatment options may be limited. UK HFpEF is a study that aims to gain a better understanding of why people develop HFpEF, develop better tests to diagnosis it, identify and test new treatments, and follow the health of the people taking part over many years.

Who May Be Eligible (Plain English)

Who May Qualify: 1. Written willing to sign a consent form 2. Diagnosis of HFpEF by a cardiologist with HF expertise, or a primary care physician with HF expertise, or a heart failure nurse 3. Natriuretic peptide levels measured Who Should NOT Join This Trial: 1. LV EF \< 40% (at screening or any previous measurement) 2. Known infiltrative cardiomyopathy (e.g., amyloid, sarcoid, lymphoma, endomyocardial fibrosis) 3. Known active myocarditis, constrictive pericarditis, or cardiac tamponade 4. Known genetic hypertrophic cardiomyopathy or obstructive hypertrophic cardiomyopathy 5. Known arrhythmogenic right ventricular cardiomyopathy 6. Known severe primary valvular heart disease 7. Known idiopathic, heritable or drug-induced pulmonary arterial hypertension 8. Heart transplantation or ventricular assist device 9. Complex congenital heart disease Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: 1. Written informed consent 2. Diagnosis of HFpEF by a cardiologist with HF expertise, or a primary care physician with HF expertise, or a heart failure nurse 3. Natriuretic peptide levels measured Exclusion Criteria: 1. LV EF \< 40% (at screening or any previous measurement) 2. Known infiltrative cardiomyopathy (e.g., amyloid, sarcoid, lymphoma, endomyocardial fibrosis) 3. Known active myocarditis, constrictive pericarditis, or cardiac tamponade 4. Known genetic hypertrophic cardiomyopathy or obstructive hypertrophic cardiomyopathy 5. Known arrhythmogenic right ventricular cardiomyopathy 6. Known severe primary valvular heart disease 7. Known idiopathic, heritable or drug-induced pulmonary arterial hypertension 8. Heart transplantation or ventricular assist device 9. Complex congenital heart disease

Locations (20)

Cwm Taf Morgannwg University Health Board
Abercynon, United Kingdom
Buckinghamshire Healthcare NHS Trust
Aylesbury, United Kingdom
University Hospitals Birmingham NHS Foundation Trust
Birmingham, United Kingdom
Broomfield Hospital
Chelmsford, United Kingdom
NHS Tayside
Dundee, United Kingdom
Glasgow Royal Infirmary
Glasgow, United Kingdom
West Suffolk NHS Foundation Trust
Ipswich, United Kingdom
Kettering General Hospital
Kettering, United Kingdom
Leeds Teaching Hospitals NHS Trust
Leeds, United Kingdom
University Hospitals of Leicester NHS Foundation Trust
Leicester, United Kingdom
Barnet Hospital
London, United Kingdom
Guys and St. Thomas' NHS Foundation Trust
London, United Kingdom
Imperial College Healthcare NHS Trust
London, United Kingdom
Manchester University NHS Foundation trust
Manchester, United Kingdom
The James Cook University Hospital
Middlesbrough, United Kingdom
Northumbria Healthcare NHS Foundation Trust
Newcastle upon Tyne, United Kingdom
Norfolk & Norwich University Hospitals NHS Foundation Trust
Norwich, United Kingdom
George Eliot Hospital
Nuneaton, United Kingdom
North West Anglia NHS Foundation Trust
Peterborough, United Kingdom
University Hospitals Dorset NHS Foundation Trust
Poole, United Kingdom