Exploring the Recovery Function of Sleep in Neurodegeneration

Who May Qualify: - Good general health or confirmed diagnosis of neurodegenerative disease associated with abnormal protein aggregation along international criteria - Age above 18 years - In ambulant setting: ability to apply the ambulant EEG device for the duration of the study, either alone or with help of co-habitant if MoCA \< 20 Who Should NOT Join This Trial: - Failure to give willing to sign a consent form - Inability to follow the procedures of the study, e.g. due to language problems or cognitive deficits - Known or suspected non-compliance, drug- or medication abuse - Inability to hear the tones to be applied during sleep in auditory stimulation experiments - Skin disorders/problems/allergies in face/ear area that could worsen with electrode application - Regular intake of drugs that may alter the relationship between sleep and outcome variables under investigation (opioids, benzodiazepines and z-drugs (nonbenzodiazepines)). - Clinically significant concomitant disease states - Too high (disease) burden for patients - Additional non-medical exclusion criteria may be defined for certain cognitive tasks (e.g. no glasses during experiments involving eye tracking) Always talk to your doctor about whether this trial is right for you.