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RECRUITINGINTERVENTIONAL

REward SYSTem in Autism Spectrum Disorder and Addictive Disorder

Stimuli Sociaux Et Non-sociaux Du Système De Récompense : Une Étude En IRM Chez Des Sujets Avec Trouble Du Spectre De L'autisme Et Des Sujets Avec Un Trouble Addictif À L'alimentation. - RESYSTAA

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

An MRI Study in Subjects with Autism Spectrum Disorder and Subjects with Food Addictive Disorder compared to healthy volunteers.

Who May Be Eligible (Plain English)

Who May Qualify: Arm A ˗ Concerning ASD patients: Adult carrying the diagnosis of ASD (DSM-5, ADOS, ADI-R criteria) Arm B ˗ Concerning FAD patients: Adult diagnosed with FA presenting with food addiction (DSM-5, YFAS 2.0, BES \>= 18 criteria). Arm C ˗ Concerning healthy volunteers : Adult with no neurological and psychiatric history , absence of progressive somatic pathologies or with vital risk. For all participants: - Age greater than or equal to 18 years old - Without intellectual delay (IQ \> 70). - Able to understand and apply the instruction when an active task is proposed, according to the estimate of the investigator. - Free, express, informed and written consent of the participant. - Participant affiliated to a social security scheme Who Should NOT Join This Trial: - Neuromotor disorders. - Visual disturbances not corrected or incompatible with MRI. - Known epilepsy. - Current substance use disorder with emotional distress/significant impact on functional outcome - Rare genetic syndrome. - Contraindications to MRI (other than body circumference) - For women of childbearing age: negative urine or blood pregnancy test - Person subject to a measure of judicial protection (safeguard of justice, curatorship, guardianship or family authorization) Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: Arm A ˗ Concerning ASD patients: Adult carrying the diagnosis of ASD (DSM-5, ADOS, ADI-R criteria) Arm B ˗ Concerning FAD patients: Adult diagnosed with FA presenting with food addiction (DSM-5, YFAS 2.0, BES \>= 18 criteria). Arm C ˗ Concerning healthy volunteers : Adult with no neurological and psychiatric history , absence of progressive somatic pathologies or with vital risk. For all participants: * Age greater than or equal to 18 years old * Without intellectual delay (IQ \> 70). * Able to understand and apply the instruction when an active task is proposed, according to the estimate of the investigator. * Free, express, informed and written consent of the participant. * Participant affiliated to a social security scheme Exclusion Criteria: * Neuromotor disorders. * Visual disturbances not corrected or incompatible with MRI. * Known epilepsy. * Current substance use disorder with emotional distress/significant impact on functional outcome * Rare genetic syndrome. * Contraindications to MRI (other than body circumference) * For women of childbearing age: negative urine or blood pregnancy test * Person subject to a measure of judicial protection (safeguard of justice, curatorship, guardianship or family authorization)

Treatments Being Tested

DIAGNOSTIC_TEST

MRI

an fMRI measurement of the BOLD physiological signal for sensory responses

DIAGNOSTIC_TEST

EEG

These tests, through videos with a social or non-social content (human presence or absence on the stereoscopic projection), will allow us to study two types of sensorialities (visual and interoceptive). Thus, it will be possible to obtain inter- and exteroceptive profiles of the participants, a direct reflection of the processing of the internal bodily sensations of the body.

Locations (3)

Center-Val de Loire Region Autism Resource Center
Tours, France
University Addictology Service, Liaison Team and Addictology Care
Tours, France
University Hospital, Medical Imaging Service
Tours, France