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RECRUITINGPhase 2INTERVENTIONAL

Cannabis' Impact on Alcohol Consumption

Cannabis' Impact on Alcohol Consumption: Integrating Laboratory and Ecological Momentary Assessment Methods

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

This study employs a repeated measures experimental design to examine the effect of THC-dominant dose of cannabis and CBD-dominant dose of cannabis, relative to placebo, on subsequent drinking in an alcohol choice task in which participants choose either to drink or receive monetary reinforcement for drinks not consumed. Cannabis will be administered simultaneously with an alcohol-priming dose or alcohol placebo. The study will enroll up to 350 nontreatment-seeking heavy episodic alcohol drinkers who use cannabis weekly.

Who May Be Eligible (Plain English)

Who May Qualify: - Age 21 to 50 - English-speaking - cannabis smoking in past two months - heavy drinking in past two months - in good physical health and weighing \< 250 lbs - zero breath alcohol at each visit Who Should NOT Join This Trial: - positive pregnancy test - nursing - positive urine toxicology screen for drugs other than cannabis - interest to quit or receive treatment for cannabis or alcohol use Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Age 21 to 50 * English-speaking * cannabis smoking in past two months * heavy drinking in past two months * in good physical health and weighing \< 250 lbs * zero breath alcohol at each visit Exclusion Criteria: * positive pregnancy test * nursing * positive urine toxicology screen for drugs other than cannabis * interest to quit or receive treatment for cannabis or alcohol use

Treatments Being Tested

DRUG

THC-dominant cannabis

Smoked cannabis with 9.53% THC and 0.09% CBD

DRUG

CBD-dominant cannabis

Smoked cannabis with 0.35% THC and 11.27% CBD

DRUG

Cannabis placebo

Smoked placebo cannabis plant material

DRUG

Alcohol

Drink containing 0.3 g/kg of alcohol

DRUG

Alcohol placebo

Placebo beverage contains only juice and a negligible trace of alcohol for masking

Locations (1)

Brown University
Providence, Rhode Island, United States