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RECRUITINGINTERVENTIONAL

Thermotherapy Against Persistent Bacterial LUNG Infections

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The aim of this study is to determine whether an intervention with frequent thermotherapy will be able to reduce the amount of colonizing bacteria in the bronchoalveolar lavage sample and eradicate the colonizing bacteria.

Who May Be Eligible (Plain English)

Who May Qualify: - Age ≥ 18 years - Competent and capable - FEV1\>1,0 L - Have had a positive culture from sputum or BAL min. 2 times in the last 24 months for bacteria of the species: Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Staphylococcus aureus, Haemophilus influenzae, Achromobacter xylosoxidans, Klebsiella oxytoca or Klebsiella pneumoniae. In addition, min. 1 positive culture after treatment with antibiotics - Willing to go to a sauna (min. temperature of 85℃ for at least 7 minutes) four times weekly for six months or avoid going to a sauna for six months Who Should NOT Join This Trial: - Allergy to lidocaine and/or midazolam - Contraindications to bronchoscopy - Previous severe laryngospasm (intubation requiring) - Pregnancy/breastfeeding - Severe linguistic problems or inability to give willing to sign a consent form - Severe mental illness that is not controlled with medication. NB: Patients with controlled mental illness can be included and will be asked on an equal footing as others Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Age ≥ 18 years * Competent and capable * FEV1\>1,0 L * Have had a positive culture from sputum or BAL min. 2 times in the last 24 months for bacteria of the species: Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Staphylococcus aureus, Haemophilus influenzae, Achromobacter xylosoxidans, Klebsiella oxytoca or Klebsiella pneumoniae. In addition, min. 1 positive culture after treatment with antibiotics * Willing to go to a sauna (min. temperature of 85℃ for at least 7 minutes) four times weekly for six months or avoid going to a sauna for six months Exclusion Criteria: * Allergy to lidocaine and/or midazolam * Contraindications to bronchoscopy * Previous severe laryngospasm (intubation requiring) * Pregnancy/breastfeeding * Severe linguistic problems or inability to give informed consent * Severe mental illness that is not controlled with medication. NB: Patients with controlled mental illness can be included and will be asked on an equal footing as others

Treatments Being Tested

OTHER

Thermotherapy/sauna bath

Thermotherapy/sauna bath

Locations (1)

Herlev and Gentofte University hospital
Hellerup, Capital Region, Denmark