Emergency PWAS in Respiratory Infectious Disease

Who May Qualify: Patients eligible for enrolment include: With reference to previous inclusion criteria are: - Adults ≥18 years of age; AND - Suspected, acute, community-acquired, respiratory, infectious disease (scaRID)\*; AND - willing to sign a consent form. Note: scaRID is defined according to ALL three criteria: 1. Community acquired (not hospitalised for \<28 days); AND 2. Acute infection (defined as symptom onset \<8 days and any ONE of reported fever or chills or aural temperature \>37.5°C or hypothermia or leucocytosis or leucopaenia or new altered mental status); AND 3. Probable respiratory infection - According to any ONE of: 1. new cough or new sputum production or 2. chest pain or 3. dyspnoea or 4. tachypnoea or 5. abnormal lung examination or 6. respiratory failure; or 7. physician's judgment (presenting with systemic or gastrointestinal symptoms). Control subjects will be drawn from two groups: - The worried well - adult patients with a National Early Warning Score (NEWS) \<3 and a temperature \<37.5°C. - Relatives or accompanying friends with no acute illness. Who Should NOT Join This Trial: - Refusal of consent; - Recent hospitalisation (\<28 days); - Enrolled in another clinical trial - Cellulitis; - Skin or orthopaedic infections; - Urinary tract infection; - Acute abdominal sepsis; - Sexual transmitted disease; - Human weakened immune system virus (HIV) infection; - Immunocompromised/potential neutropenic fever; - Solid organ or haematopoietic stem-cell transplant within the previous 90 days; - Active graft-versus-host disease or bronchiolitis obliterans; - Severe traveller's disease requiring urgent hospitalisation and management including malaria, dengue, typhoid and other rickettsial diseases; - Stroke; - Toxidrome; - Non-organic acute psychosis. Always talk to your doctor about whether this trial is right for you.