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RECRUITINGOBSERVATIONAL

Tracking of Upper Limb Sensory and Motor Recovery in Asian Stroke Survivors

Deep Phenotyping of Upper Limb Sensori-motor Recovery in Asian Stroke Survivors: Concept, Development and Implementation of a Rehabilomics-driven Technology-assisted Data Platform

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

As Singapore's population is aging rapidly, the incidence rate of stroke has been increasing in the past years. Rehabilitation is essential for the resumption of daily activities, and with the appropriate care, it is possible for stroke-survivors to regain most of their functions. Hence, this study aims to better understand upper limb recovery covering different stages post-stroke in a representative cohort of Asian adults

Who May Be Eligible (Plain English)

Who May Qualify: 1. Stroke confirmed by neurologists, neurosurgeons and brain imaging (CT, CT angiogram, MRI, MR angiogram) 2. First ever confirmed stroke 3. Asian ethnicity 4. Age 21-90 years 5. Montreal Cognitive Assessment (MOCA) scores 21/30 and above 6. Admission to rehabilitation ward is within 8 weeks of stroke onset Who Should NOT Join This Trial: 1. Recurrent stroke or transient ischaemic attack (TIA) 2. Upper limb impairment not related to stroke: e.g., subarachnoid haemorrhage, traumatic brain injury or brain tumours 3. Bilateral upper limb impairment. 4. Uncontrolled medical conditions such as hypertension, hypotension, diabetes mellitus, unstable angina, cardiac failure or sepsis will be excluded. 5. Active fractures or arthritis of upper limb joints/bones 6. Visual Analogue Scale (VAS) pain \> 5/10 7. MOCA \< 21/30 8. Severe behavioural disturbance or agitation or epilepsy or untreated depression 9. Life expectancy \< 6 months 10. End organ failures on replacements (renal dialysis or renal replacement therapies) 11. Minimally responsive or unresponsive awareness (vegetative) states 12. Pregnancy or lactation states 13. Admission to rehab ward later than 8 weeks post-stroke 14. (For TMS assessments only) History of epilepsy or seizures, or cranial surgeries, or have metal implants in body or head, or have implanted electronics, or have metallic valve, or skull fracture or brain injury, or head or brain surgeries. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: 1. Stroke confirmed by neurologists, neurosurgeons and brain imaging (CT, CT angiogram, MRI, MR angiogram) 2. First ever confirmed stroke 3. Asian ethnicity 4. Age 21-90 years 5. Montreal Cognitive Assessment (MOCA) scores 21/30 and above 6. Admission to rehabilitation ward is within 8 weeks of stroke onset Exclusion Criteria: 1. Recurrent stroke or transient ischaemic attack (TIA) 2. Upper limb impairment not related to stroke: e.g., subarachnoid haemorrhage, traumatic brain injury or brain tumours 3. Bilateral upper limb impairment. 4. Uncontrolled medical conditions such as hypertension, hypotension, diabetes mellitus, unstable angina, cardiac failure or sepsis will be excluded. 5. Active fractures or arthritis of upper limb joints/bones 6. Visual Analogue Scale (VAS) pain \> 5/10 7. MOCA \< 21/30 8. Severe behavioural disturbance or agitation or epilepsy or untreated depression 9. Life expectancy \< 6 months 10. End organ failures on replacements (renal dialysis or renal replacement therapies) 11. Minimally responsive or unresponsive awareness (vegetative) states 12. Pregnancy or lactation states 13. Admission to rehab ward later than 8 weeks post-stroke 14. (For TMS assessments only) History of epilepsy or seizures, or cranial surgeries, or have metal implants in body or head, or have implanted electronics, or have metallic valve, or skull fracture or brain injury, or head or brain surgeries.

Treatments Being Tested

OTHER

Clinical and technological-aided assessments and questionnaires

Assessments and questionnaires related to upper limb function and quality of life will be used

Locations (1)

Tan Tock Seng Hospital
Singapore, Singapore