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RECRUITINGINTERVENTIONAL

Effect of Circadian Rhythm and Physical Exercise in Overweight Type 1 Diabetes Patients

Elucidating the Interplay Between Circadian Rhythm and Physical Exercise on Metabolism in Patients With Type 1 Diabetes and Overweight

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Cardiometabolic risk in patients with abdominal obesity and type 1 diabetes can be moderated by life style modifications. There is an intimate link between gene regulation and circadian rhythm in mediating response to exercise in a variety of insulin sensitive organs. The aim of this project is to evaluate, by intervention, the interplay of circadian rhythm and high intensity interval training (HIIT) on glucose control and skeletal muscle metabolism in patients with overweight with or without type 1 diabetes (T1D).

Who May Be Eligible (Plain English)

Who May Qualify: - BMI 25-30 - type 1 diabetes or healthy subjects Who Should NOT Join This Trial: - nicotine usage, - cardiovascular disease (CVD), - blood pressure \>160/95, - pregnancy, - treatment with other pharmaceutical drugs than insulin, stable dose of thyroid hormone, statins, and antihypertensive drugs (excluding beta blockers). Additional exclusion criteria for diabetes subjects: - diabetes duration less than 6 months, - proliferative or severe non-proliferative retinopathy, - chronic kidney disease with glomerular filtration rate (GFR) \<60 ml/min, Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * BMI 25-30 * type 1 diabetes or healthy subjects Exclusion Criteria: * nicotine usage, * cardiovascular disease (CVD), * blood pressure \>160/95, * pregnancy, * treatment with other pharmaceutical drugs than insulin, stable dose of thyroid hormone, statins, and antihypertensive drugs (excluding beta blockers). Additional exclusion criteria for diabetes subjects: * diabetes duration less than 6 months, * proliferative or severe non-proliferative retinopathy, * chronic kidney disease with glomerular filtration rate (GFR) \<60 ml/min,

Treatments Being Tested

BEHAVIORAL

High intensity interval training (HIIT)

HIIT performed either in the morning or in the afternoon

Locations (1)

Ersta sjukhus
Stockholm, Sweden