RECRUITINGOBSERVATIONAL
Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes
About This Trial
Fibromyalgia (FM) is a chronic musculoskeletal pain disorder that afflicts up to 4% of the general population. The evaluation of pain mechanisms in FM has shown predominant central abnormalities and therefore has been designated as nociplastic pain syndrome. Rheumatoid arthritis (RA) is characterized by polyarthritis and pain from inflamed tissues, consistent with nociceptive pain. FM and RA patients may utilize overlapping pain mechanisms resulting in nociceptive and nociplastic pain.
Who May Be Eligible (Plain English)
Who May Qualify:
- Ages 18-70
- Fulfills the 1990 and 2011 American College of Rheumatology Criteria for FM
- Fulfills the 2010 ACR-EULAR classification criteria for RA
- Healthy volunteers: No significant pain/fatigue/depression/anxiety.
Who Should NOT Join This Trial:
- Diabetes
- Cancer
- Advanced liver, kidney or cardiovascular disease
- Neuropathic pain
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* Ages 18-70
* Fulfills the 1990 and 2011 American College of Rheumatology Criteria for FM
* Fulfills the 2010 ACR-EULAR classification criteria for RA
* Healthy volunteers: No significant pain/fatigue/depression/anxiety.
Exclusion Criteria:
* Diabetes
* Cancer
* Advanced liver, kidney or cardiovascular disease
* Neuropathic pain
Locations (1)
University of Florida
Gainesville, Florida, United States