Skip to main content
TrialFinder
TrialFinder is for informational purposes only and does not provide medical advice. Always talk to your doctor about whether a trial is right for you.
RECRUITINGOBSERVATIONAL

Recovery Rate in Secondary Hypothyroidism

Rate of Recovery of Secondary Hypothyroidism in Patients With Pituitary Disorders.

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The aim of this project is to assess the rate of recovery of secondary hypothyroidism in patients with pituitary disorders.

Who May Be Eligible (Plain English)

Who May Qualify: - Confirmed diagnosis of secondary hypothyroidism who are currently taking T4 replacement therapy Who Should NOT Join This Trial: - uncontrolled cardiovascular disease - uncontrolled congestive heart failure - uncontrolled mental health disorder - not adequately replaced and have low T4 level. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Confirmed diagnosis of secondary hypothyroidism who are currently taking T4 replacement therapy Exclusion Criteria: * uncontrolled cardiovascular disease * uncontrolled congestive heart failure * uncontrolled mental health disorder * not adequately replaced and have low T4 level.

Treatments Being Tested

DRUG

Levothyroxine

Step 1: * Reduce the dose of T4 therapy by 50% and recheck serum T4 after 2 weeks. * If serum T4 is normal, go to step 2. * If serum T4 drops to below normal then resume full T4 replacement (these patients will be considered as having withdrawal failure). Step 2: * Discontinue T4 therapy altogether and recheck serum TSH and T4 after 2 weeks. * If serum T4 is normal, go to step 3. * If serum T4 drops to below normal then resume full T4 replacement (these patients will be considered as having withdrawal failure). Step 3: * Recheck serum TSH and T4 after 8 weeks. * If serum TSH and T4 levels are normal, these patients will be regarded as having successful T4 withdrawal. * If T4 drops to below normal then resume full T4 replacement (these patients will be considered as having withdrawal failure).

Locations (1)

Nova Scotia Health
Halifax, Canada